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Do blood-borne calcifying nanoparticles self-propagate?

The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus,...

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Detalles Bibliográficos
Autores principales: Mathew, Grace, McKay, David S, Çiftçioglu, Neva
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527661/
https://www.ncbi.nlm.nih.gov/pubmed/18686786
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author Mathew, Grace
McKay, David S
Çiftçioglu, Neva
author_facet Mathew, Grace
McKay, David S
Çiftçioglu, Neva
author_sort Mathew, Grace
collection PubMed
description The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact of a nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry.
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spelling pubmed-25276612008-10-01 Do blood-borne calcifying nanoparticles self-propagate? Mathew, Grace McKay, David S Çiftçioglu, Neva Int J Nanomedicine Original Research The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact of a nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry. Dove Medical Press 2008-06 2008-06 /pmc/articles/PMC2527661/ /pubmed/18686786 Text en © 2008 Mathew et al, publisher and licensee Dove Medical Press Ltd.
spellingShingle Original Research
Mathew, Grace
McKay, David S
Çiftçioglu, Neva
Do blood-borne calcifying nanoparticles self-propagate?
title Do blood-borne calcifying nanoparticles self-propagate?
title_full Do blood-borne calcifying nanoparticles self-propagate?
title_fullStr Do blood-borne calcifying nanoparticles self-propagate?
title_full_unstemmed Do blood-borne calcifying nanoparticles self-propagate?
title_short Do blood-borne calcifying nanoparticles self-propagate?
title_sort do blood-borne calcifying nanoparticles self-propagate?
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527661/
https://www.ncbi.nlm.nih.gov/pubmed/18686786
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