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Do blood-borne calcifying nanoparticles self-propagate?
The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus,...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Dove Medical Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527661/ https://www.ncbi.nlm.nih.gov/pubmed/18686786 |
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author | Mathew, Grace McKay, David S Çiftçioglu, Neva |
author_facet | Mathew, Grace McKay, David S Çiftçioglu, Neva |
author_sort | Mathew, Grace |
collection | PubMed |
description | The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact of a nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry. |
format | Text |
id | pubmed-2527661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25276612008-10-01 Do blood-borne calcifying nanoparticles self-propagate? Mathew, Grace McKay, David S Çiftçioglu, Neva Int J Nanomedicine Original Research The nanotechnology industry is currently in the process of producing new nanoparticles. The biological activity of nanoparticles including adverse as well as beneficial effects tends to increase as their size decreases. The smaller the particles are, the greater their bioactivity and toxicity. Thus, one can easily conjecture the impact of a nanoparticle if it could also self-replicate. This in vitro study reveals the self-propagating ability of unique calcifying nanoparticles (CNP) that can be as small as 50 nm in size and found in blood, blood products, and calcified soft tissues. Although specific detection techniques, morphological characteristics and biomineralizing properties of CNP are well established, their genomic information and self-propagating capability have always been challenged. The objective of this study is to document the propagation of CNP under physiological conditions, using inverted light microscopy (LM) and the Biostation IM time-lapse imaging system. Their detailed morphological structure was examined using scanning (SEM) and transmission (TEM) electron microscopy. This present study, in conjunction with previous findings of metabolic activity, antibiotic sensitivity, antibody specificity, morphological aspects and infectivity, validates CNP as self-replicators. Therefore these sterile-filterable, blood-borne nanoparticles should be of concern to the nanomedicine industry. Dove Medical Press 2008-06 2008-06 /pmc/articles/PMC2527661/ /pubmed/18686786 Text en © 2008 Mathew et al, publisher and licensee Dove Medical Press Ltd. |
spellingShingle | Original Research Mathew, Grace McKay, David S Çiftçioglu, Neva Do blood-borne calcifying nanoparticles self-propagate? |
title | Do blood-borne calcifying nanoparticles self-propagate? |
title_full | Do blood-borne calcifying nanoparticles self-propagate? |
title_fullStr | Do blood-borne calcifying nanoparticles self-propagate? |
title_full_unstemmed | Do blood-borne calcifying nanoparticles self-propagate? |
title_short | Do blood-borne calcifying nanoparticles self-propagate? |
title_sort | do blood-borne calcifying nanoparticles self-propagate? |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527661/ https://www.ncbi.nlm.nih.gov/pubmed/18686786 |
work_keys_str_mv | AT mathewgrace dobloodbornecalcifyingnanoparticlesselfpropagate AT mckaydavids dobloodbornecalcifyingnanoparticlesselfpropagate AT ciftciogluneva dobloodbornecalcifyingnanoparticlesselfpropagate |