Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?

Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing. This review highlights the promising data for their combination with a wide range of established and novel anticancer agents and discusses the mechanisms that underpin these interactions.

Detalles Bibliográficos
Autores principales: Nolan, L, Johnson, P W M, Ganesan, A, Packham, G, Crabb, S J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528143/
https://www.ncbi.nlm.nih.gov/pubmed/18728657
http://dx.doi.org/10.1038/sj.bjc.6604557
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author Nolan, L
Johnson, P W M
Ganesan, A
Packham, G
Crabb, S J
author_facet Nolan, L
Johnson, P W M
Ganesan, A
Packham, G
Crabb, S J
author_sort Nolan, L
collection PubMed
description Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing. This review highlights the promising data for their combination with a wide range of established and novel anticancer agents and discusses the mechanisms that underpin these interactions.
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spelling pubmed-25281432009-09-11 Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential? Nolan, L Johnson, P W M Ganesan, A Packham, G Crabb, S J Br J Cancer Minireview Histone deacetylase inhibitors have progressed rapidly from the laboratory to clinical testing. This review highlights the promising data for their combination with a wide range of established and novel anticancer agents and discusses the mechanisms that underpin these interactions. Nature Publishing Group 2008-09-02 2008-08-19 /pmc/articles/PMC2528143/ /pubmed/18728657 http://dx.doi.org/10.1038/sj.bjc.6604557 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Nolan, L
Johnson, P W M
Ganesan, A
Packham, G
Crabb, S J
Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
title Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
title_full Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
title_fullStr Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
title_full_unstemmed Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
title_short Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
title_sort will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528143/
https://www.ncbi.nlm.nih.gov/pubmed/18728657
http://dx.doi.org/10.1038/sj.bjc.6604557
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