Role of LKB1 in lung cancer development

Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unch...

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Detalles Bibliográficos
Autores principales: Makowski, L, Hayes, D N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528145/
https://www.ncbi.nlm.nih.gov/pubmed/18728656
http://dx.doi.org/10.1038/sj.bjc.6604515
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author Makowski, L
Hayes, D N
author_facet Makowski, L
Hayes, D N
author_sort Makowski, L
collection PubMed
description Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation.
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spelling pubmed-25281452009-09-11 Role of LKB1 in lung cancer development Makowski, L Hayes, D N Br J Cancer Minireview Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation. Nature Publishing Group 2008-09-02 2008-08-19 /pmc/articles/PMC2528145/ /pubmed/18728656 http://dx.doi.org/10.1038/sj.bjc.6604515 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Makowski, L
Hayes, D N
Role of LKB1 in lung cancer development
title Role of LKB1 in lung cancer development
title_full Role of LKB1 in lung cancer development
title_fullStr Role of LKB1 in lung cancer development
title_full_unstemmed Role of LKB1 in lung cancer development
title_short Role of LKB1 in lung cancer development
title_sort role of lkb1 in lung cancer development
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528145/
https://www.ncbi.nlm.nih.gov/pubmed/18728656
http://dx.doi.org/10.1038/sj.bjc.6604515
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