Chromatin profiling across the human tumour necrosis factor gene locus reveals a complex, cell type-specific landscape with novel regulatory elements

The TNF locus on chromosome 6p21 encodes a family of proteins with key roles in the immune response whose dysregulation leads to severe disease. Transcriptional regulation is important, with cell type and stimulus-specific enhancer complexes involving the proximal TNF promoter. We show how quantitat...

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Detalles Bibliográficos
Autores principales: Taylor, Jennifer M., Wicks, Kate, Vandiedonck, Claire, Knight, Julian C.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528168/
https://www.ncbi.nlm.nih.gov/pubmed/18653526
http://dx.doi.org/10.1093/nar/gkn444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528168/
https://www.ncbi.nlm.nih.gov/pubmed/18653526
http://dx.doi.org/10.1093/nar/gkn444

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