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XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells

XRCC1 is a critical scaffold protein that orchestrates efficient single-strand break repair (SSBR). Recent data has found an association of XRCC1 with proteins causally linked to human spinocerebellar ataxias—aprataxin and tyrosyl-DNA phosphodiesterase 1—implicating SSBR in protection against neuron...

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Detalles Bibliográficos
Autores principales:	Kulkarni, Avanti, McNeill, Daniel R., Gleichmann, Marc, Mattson, Mark P., Wilson, David M.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528184/ https://www.ncbi.nlm.nih.gov/pubmed/18682529 http://dx.doi.org/10.1093/nar/gkn480

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