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Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients

BACKGROUND: Improvements in ventilatory mechanics with tiotropium increases exercise tolerance during pulmonary rehabilitation. We wondered whether tiotropium also increased physical activities outside of pulmonary rehabilitation. METHODS: COPD patients participating in 8 weeks of pulmonary rehabili...

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Autores principales: Kesten, Steven, Casaburi, Richard, Kukafka, David, Cooper, Christopher B
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528216/
https://www.ncbi.nlm.nih.gov/pubmed/18488436
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author Kesten, Steven
Casaburi, Richard
Kukafka, David
Cooper, Christopher B
author_facet Kesten, Steven
Casaburi, Richard
Kukafka, David
Cooper, Christopher B
author_sort Kesten, Steven
collection PubMed
description BACKGROUND: Improvements in ventilatory mechanics with tiotropium increases exercise tolerance during pulmonary rehabilitation. We wondered whether tiotropium also increased physical activities outside of pulmonary rehabilitation. METHODS: COPD patients participating in 8 weeks of pulmonary rehabilitation were studied in a randomized, double-blind, placebo-controlled trial of tiotropium 18 μg daily (tiotropium = 47, placebo = 44). Study drug was administered for 5 weeks prior to, 8 weeks during, and 12 weeks following pulmonary rehabilitation. Patients completed a questionnaire documenting participation in pre-defined activities outside of pulmonary rehabilitation during the 2 weeks prior to each visit. Patients who submitted an activity questionnaire at week 4 and on at least one subsequent visit were included in the analysis. For each patient, the number of sessions was multiplied with the duration of each activity and then summed to give overall activity duration. RESULTS: Patients (n = 46) had mean age of 67 years, mean baseline FEV(1) of 0.84 L (33% predicted). Mean (SE) increase in duration of activities (minutes during 2 weeks prior to each visit) from week 4 (prior to PR) to week 13 (end of PR) was 145 (84) minutes with tiotropium and 66 (96) minutes with placebo. The increase from week 4 to week 25 (end of follow-up) was 262 (96) and 60 (93) minutes for the respective groups. Increases in activity duration from week 4 to weeks 17, 21, and 25 were statistically significant with tiotropium. No statistical differences over time were observed within the placebo-treated group and differences between groups were not significant. CONCLUSIONS: Tiotropium appears to amplify the effectiveness of pulmonary rehabilitation as seen by increases in patient self-reported participation in physical activities.
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spelling pubmed-25282162009-05-04 Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients Kesten, Steven Casaburi, Richard Kukafka, David Cooper, Christopher B Int J Chron Obstruct Pulmon Dis Original Research BACKGROUND: Improvements in ventilatory mechanics with tiotropium increases exercise tolerance during pulmonary rehabilitation. We wondered whether tiotropium also increased physical activities outside of pulmonary rehabilitation. METHODS: COPD patients participating in 8 weeks of pulmonary rehabilitation were studied in a randomized, double-blind, placebo-controlled trial of tiotropium 18 μg daily (tiotropium = 47, placebo = 44). Study drug was administered for 5 weeks prior to, 8 weeks during, and 12 weeks following pulmonary rehabilitation. Patients completed a questionnaire documenting participation in pre-defined activities outside of pulmonary rehabilitation during the 2 weeks prior to each visit. Patients who submitted an activity questionnaire at week 4 and on at least one subsequent visit were included in the analysis. For each patient, the number of sessions was multiplied with the duration of each activity and then summed to give overall activity duration. RESULTS: Patients (n = 46) had mean age of 67 years, mean baseline FEV(1) of 0.84 L (33% predicted). Mean (SE) increase in duration of activities (minutes during 2 weeks prior to each visit) from week 4 (prior to PR) to week 13 (end of PR) was 145 (84) minutes with tiotropium and 66 (96) minutes with placebo. The increase from week 4 to week 25 (end of follow-up) was 262 (96) and 60 (93) minutes for the respective groups. Increases in activity duration from week 4 to weeks 17, 21, and 25 were statistically significant with tiotropium. No statistical differences over time were observed within the placebo-treated group and differences between groups were not significant. CONCLUSIONS: Tiotropium appears to amplify the effectiveness of pulmonary rehabilitation as seen by increases in patient self-reported participation in physical activities. Dove Medical Press 2008-03 2008-03 /pmc/articles/PMC2528216/ /pubmed/18488436 Text en © 2008 Kesten et al, publisher and licensee Dove Medical Press Ltd.
spellingShingle Original Research
Kesten, Steven
Casaburi, Richard
Kukafka, David
Cooper, Christopher B
Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
title Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
title_full Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
title_fullStr Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
title_full_unstemmed Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
title_short Improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in COPD patients
title_sort improvement in self-reported exercise participation with the combination of tiotropium and rehabilitative exercise training in copd patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528216/
https://www.ncbi.nlm.nih.gov/pubmed/18488436
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