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Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

BACKGROUND AND PURPOSE: GPR119 is a G protein-coupled receptor that is preferentially expressed in islet cells and mediates insulin secretion. Oleoyl-lysophosphatidylcholine and oleoylethanolamide (OEA) act as endogenous ligands for this receptor, whereas PSN375963 and PSN632408 are two recently rep...

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Detalles Bibliográficos
Autores principales:	Ning, Y, O'Neill, K, Lan, H, Pang, L, Shan, L X, Hawes, B E, Hedrick, J A
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2008
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2528830/ https://www.ncbi.nlm.nih.gov/pubmed/18724386 http://dx.doi.org/10.1038/bjp.2008.337

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