Cargando…

Inadequate Activation of the GTPase RhoA Contributes to the Lack of Fibronectin Matrix Assembly in von Hippel-Lindau Protein-defective Renal Cancer Cells

The von Hippel-Lindau (VHL) tumor suppressor gene regulates extracellular matrix deposition. In VHL negative renal cancer cells, VHL(-), the lack of fibronectin matrix assembly is thought to promote and maintain tumor angiogenesis allowing vessels to infiltrate tumors. Therefore, and considering the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feijóo-Cuaresma, Monica, Méndez, Fernando, Maqueda, Alfredo, Esteban, Miguel A., Naranjo-Suarez, Salvador, Castellanos, Maria C., del Cerro, Mercedes Hernández, Vazquez, Silvia N., García-Pardo, Angeles, Landázuri, Manuel O., Calzada, Maria J.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2008
Materias:	Mechanisms of Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529126/ https://www.ncbi.nlm.nih.gov/pubmed/18567581 http://dx.doi.org/10.1074/jbc.M709390200

Ejemplares similares

Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration
por: Kim, Tai Young, et al.
Publicado: (2008)

Serine 34 Phosphorylation of Rho Guanine Dissociation Inhibitor (RhoGDIα) Links Signaling from Conventional Protein Kinase C to RhoGTPase in Cell Adhesion
por: Dovas, Athanassios, et al.
Publicado: (2010)

Profilin binding couples chloride intracellular channel protein CLIC4 to RhoA–mDia2 signaling and filopodium formation
por: Argenzio, Elisabetta, et al.
Publicado: (2018)

Anchored Protein Kinase A Recruitment of Active Rac GTPase
por: Logue, Jeremy S., et al.
Publicado: (2011)

Amino Acids Activate Mammalian Target of Rapamycin (mTOR) Complex 1 without Changing Rag GTPase Guanyl Nucleotide Charging
por: Oshiro, Noriko, et al.
Publicado: (2014)

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES
por: Nouri, Kazem, et al.
Publicado: (2016)

Calmodulin Association with Connexin32-derived Peptides Suggests trans-Domain Interaction in Chemical Gating of Gap Junction Channels
por: Dodd, Ryan, et al.
Publicado: (2008)

Spatiotemporal Regulation of ERK2 by Dual Specificity Phosphatases
por: Caunt, Christopher J., et al.
Publicado: (2008)

Rac Regulates Its Effector Phospholipase Cγ(2) through Interaction with a Split Pleckstrin Homology Domain
por: Walliser, Claudia, et al.
Publicado: (2008)

A Role for the Cleaved Cytoplasmic Domain of E-cadherin in the Nucleus
por: Ferber, Emma C., et al.
Publicado: (2008)

Cysteine Substitution Mutagenesis and the Effects of Methanethiosulfonate Reagents at P2X(2) and P2X(4) Receptors Support a Core Common Mode of ATP Action at P2X Receptors
por: Roberts, Jonathan A., et al.
Publicado: (2008)

Group A Streptococcus Activates Type I Interferon Production and MyD88-dependent Signaling without Involvement of TLR2, TLR4, and TLR9
por: Gratz, Nina, et al.
Publicado: (2008)

Characterization of the Human α(1)β(1) Soluble Guanylyl Cyclase Promoter: KEY ROLE FOR NF-κB(p50) AND CCAAT-BINDING FACTORS IN REGULATING EXPRESSION OF THE NITRIC OXIDE RECEPTOR
por: Marro, Martín L., et al.
Publicado: (2008)

Mitogen-activated Protein Kinase Phosphatase-1 Represses c-Jun NH(2)-terminal Kinase-mediated Apoptosis via NF-κB Regulation
por: Wang, Zhaoqing, et al.
Publicado: (2008)

Modulation of Voltage- and Ca(2+)-dependent Gating of Ca(V)1.3 L-type Calcium Channels by Alternative Splicing of a C-terminal Regulatory Domain
por: Singh, Anamika, et al.
Publicado: (2008)

A High Affinity Hepatocyte Growth Factor-binding Site in the Immunoglobulin-like Region of Met
por: Basilico, Cristina, et al.
Publicado: (2008)

Lipid-independent Secretion of a Drosophila Wnt Protein
por: Ching, Wendy, et al.
Publicado: (2008)

Activation of 5-HT(2A/C) Receptors Counteracts 5-HT(1A) Regulation of N-Methyl-D-aspartate Receptor Channels in Pyramidal Neurons of Prefrontal Cortex
por: Yuen, Eunice Y., et al.
Publicado: (2008)

Hydrogen Peroxide Promotes Aβ Production through JNK-dependent Activation of γ-Secretase
por: Shen, Chengyong, et al.
Publicado: (2008)

Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling
por: Levin, Susan E., et al.
Publicado: (2008)

Cdk5-mediated Phosphorylation of c-Myc on Ser-62 Is Essential in Transcriptional Activation of Cyclin B1 by Cyclin G1
por: Seo, Haeng Ran, et al.
Publicado: (2008)

Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal
por: Shimokawa, Takashi, et al.
Publicado: (2008)

Thyroid Hormone Receptor α1 Follows a Cooperative CRM1/Calreticulin-mediated Nuclear Export Pathway
por: Grespin, Matthew E., et al.
Publicado: (2008)

Eag1 Expression Interferes with Hypoxia Homeostasis and Induces Angiogenesis in Tumors
por: Downie, Bryan R., et al.
Publicado: (2008)

The Sushi Domains of Secreted GABA(B1) Isoforms Selectively Impair GABA(B) Heteroreceptor Function
por: Tiao, Jim Y., et al.
Publicado: (2008)

C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest
por: Fogarty, Sarah, et al.
Publicado: (2009)

SOCS-3 Inhibits E2F/DP-1 Transcriptional Activity and Cell Cycle Progression via Interaction with DP-1
por: Masuhiro, Yoshikazu, et al.
Publicado: (2008)

Functional Ryanodine Receptors in the Plasma Membrane of RINm5F Pancreatic β-Cells
por: Rosker, Christian, et al.
Publicado: (2009)

Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide
por: Townsend, Philip D., et al.
Publicado: (2009)

Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation
por: Mines, Marjelo A., et al.
Publicado: (2009)

Physiological Involvement in pH Signaling of Vps24-mediated Recruitment of Aspergillus PalB Cysteine Protease to ESCRT-III
por: Rodríguez-Galán, Olga, et al.
Publicado: (2009)

Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell Differentiation
por: Chiang, Y. Jeffrey, et al.
Publicado: (2009)

G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2
por: Mori, Jun, et al.
Publicado: (2008)

The Polybasic Region of Rac1 Modulates Bacterial Uptake Independently of Self-association and Membrane Targeting
por: Wong, Ka-Wing, et al.
Publicado: (2008)

Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5: IMPLICATIONS FOR RESISTANCE TO TYPE I DIABETES
por: Shigemoto, Taeko, et al.
Publicado: (2009)

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria
por: Nakamura, Seiji, et al.
Publicado: (2009)

Independent β-Arrestin2 and G(q)/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
por: Kim, Jihee, et al.
Publicado: (2009)

In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin
por: Killock, David J., et al.
Publicado: (2009)

β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
por: Ahn, Seungkirl, et al.
Publicado: (2009)

A Novel “Four-component” Two-component Signal Transduction Mechanism Regulates Developmental Progression in Myxococcus xanthus
por: Jagadeesan, Sakthimala, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_4v2iaj3022avr40sqqlsfbvije