Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex

BACKGROUND: Secretory leukoproteinase inhibitor (SLPI) is an important inhibitor of neutrophil elastase (NE), a proteinase implicated in the pathogenesis of lung diseases such as COPD. SLPI also has antimicrobial and anti-inflammatory properties, but the concentration of SLPI in lung secretions in C...

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Detalles Bibliográficos
Autores principales: Sullivan, Anita L, Dafforn, Timothy, Hiemstra, Pieter S, Stockley, Robert A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529288/
https://www.ncbi.nlm.nih.gov/pubmed/18699987
http://dx.doi.org/10.1186/1465-9921-9-60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529288/
https://www.ncbi.nlm.nih.gov/pubmed/18699987
http://dx.doi.org/10.1186/1465-9921-9-60

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