Cargando…
Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism
BACKGROUND: Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was to determine whether a diagnosis of VTE increases the long-term risk of myocard...
Autores principales: | , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2531082/ https://www.ncbi.nlm.nih.gov/pubmed/18706117 http://dx.doi.org/10.1186/1477-9560-6-10 |
_version_ | 1782158961776001024 |
---|---|
author | Huerta, Consuelo Johansson, Saga Wallander, Mari-Ann Rodríguez, Luis A García |
author_facet | Huerta, Consuelo Johansson, Saga Wallander, Mari-Ann Rodríguez, Luis A García |
author_sort | Huerta, Consuelo |
collection | PubMed |
description | BACKGROUND: Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was to determine whether a diagnosis of VTE increases the long-term risk of myocardial infarction (MI). METHODS: The incidence rate (IR) and relative risk (RR) of MI in a cohort of patients with a diagnosis of VTE (n = 4890) compared with that of a control cohort without prior VTE (n = 43 382) were evaluated in the UK General Practice Research Database (GPRD). Death during follow-up was also determined. Patients were followed for up to 8 years (mean of 3 years). RESULTS: The IR of MI per 1000 person-years was 4.1 (95% CI: 3.1–5.3) for the VTE cohort and 3.5 (95% CI: 3.2–3.8) for the control cohort. The IR of MI was highest in the first year after the VTE episode, but overall differences between the two cohorts were not significant (RR of MI associated with VTE: 1.2; 95% CI: 0.9–1.6). The risk of death was higher in the VTE cohort than the control cohort, even after adjustment for cancer, heart failure and ischaemic heart disease (RR: 2.4; 95% CI: 2.2–2.6), particularly during the first year after VTE (RR: 3.8; 95% CI: 3.4–4.3). CONCLUSION: A VTE episode does not significantly increase the risk of MI, but does increase the risk of death, particularly in the first year following VTE diagnosis. |
format | Text |
id | pubmed-2531082 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-25310822008-09-06 Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism Huerta, Consuelo Johansson, Saga Wallander, Mari-Ann Rodríguez, Luis A García Thromb J Original Clinical Investigation BACKGROUND: Venous thromboembolism (VTE) and thromboembolic arterial diseases are usually considered to be distinct entities, but there is evidence to suggest that these disorders may be linked. The aim of this study was to determine whether a diagnosis of VTE increases the long-term risk of myocardial infarction (MI). METHODS: The incidence rate (IR) and relative risk (RR) of MI in a cohort of patients with a diagnosis of VTE (n = 4890) compared with that of a control cohort without prior VTE (n = 43 382) were evaluated in the UK General Practice Research Database (GPRD). Death during follow-up was also determined. Patients were followed for up to 8 years (mean of 3 years). RESULTS: The IR of MI per 1000 person-years was 4.1 (95% CI: 3.1–5.3) for the VTE cohort and 3.5 (95% CI: 3.2–3.8) for the control cohort. The IR of MI was highest in the first year after the VTE episode, but overall differences between the two cohorts were not significant (RR of MI associated with VTE: 1.2; 95% CI: 0.9–1.6). The risk of death was higher in the VTE cohort than the control cohort, even after adjustment for cancer, heart failure and ischaemic heart disease (RR: 2.4; 95% CI: 2.2–2.6), particularly during the first year after VTE (RR: 3.8; 95% CI: 3.4–4.3). CONCLUSION: A VTE episode does not significantly increase the risk of MI, but does increase the risk of death, particularly in the first year following VTE diagnosis. BioMed Central 2008-08-18 /pmc/articles/PMC2531082/ /pubmed/18706117 http://dx.doi.org/10.1186/1477-9560-6-10 Text en Copyright © 2008 Huerta et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Clinical Investigation Huerta, Consuelo Johansson, Saga Wallander, Mari-Ann Rodríguez, Luis A García Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism |
title | Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism |
title_full | Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism |
title_fullStr | Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism |
title_full_unstemmed | Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism |
title_short | Risk of myocardial infarction and overall mortality in survivors of venous thromboembolism |
title_sort | risk of myocardial infarction and overall mortality in survivors of venous thromboembolism |
topic | Original Clinical Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2531082/ https://www.ncbi.nlm.nih.gov/pubmed/18706117 http://dx.doi.org/10.1186/1477-9560-6-10 |
work_keys_str_mv | AT huertaconsuelo riskofmyocardialinfarctionandoverallmortalityinsurvivorsofvenousthromboembolism AT johanssonsaga riskofmyocardialinfarctionandoverallmortalityinsurvivorsofvenousthromboembolism AT wallandermariann riskofmyocardialinfarctionandoverallmortalityinsurvivorsofvenousthromboembolism AT rodriguezluisagarcia riskofmyocardialinfarctionandoverallmortalityinsurvivorsofvenousthromboembolism |