Cargando…

Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque

BACKGROUND: Non-invasive 3-dimensional (3D) ultrasound (US) has emerged as the predominant approach for evaluating the progression of carotid atherosclerosis and its response to treatment. The aim of this study was to investigate the quality of a central reading procedure concerning plaque volume (P...

Descripción completa

Detalles Bibliográficos
Autores principales: Ludwig, Malte, Zielinski, Tomasz, Schremmer, Dieter, Stumpe, Klaus O
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2531085/
https://www.ncbi.nlm.nih.gov/pubmed/18727816
http://dx.doi.org/10.1186/1476-7120-6-42
_version_ 1782158962478546944
author Ludwig, Malte
Zielinski, Tomasz
Schremmer, Dieter
Stumpe, Klaus O
author_facet Ludwig, Malte
Zielinski, Tomasz
Schremmer, Dieter
Stumpe, Klaus O
author_sort Ludwig, Malte
collection PubMed
description BACKGROUND: Non-invasive 3-dimensional (3D) ultrasound (US) has emerged as the predominant approach for evaluating the progression of carotid atherosclerosis and its response to treatment. The aim of this study was to investigate the quality of a central reading procedure concerning plaque volume (PV), measured by 3D US in a multinational US trial. METHODS: Two data sets of 45 and 60 3D US patient images of plaques (mean PV, 71.8 and 39.8 μl, respectively) were used. PV was assessed by means of manual planimetry. The intraclass correlation coefficient (ICC) was applied to determine reader variabilities. The repeatability coefficient (RC) and the coefficient of variation (CV) were used to investigate the effect of number of slices (S) in manual planimetry and plaque size on measurement variability. RESULTS: Intra-reader variability was small as reflected by ICCs of 0.985, 0.967 and 0.969 for 3 appointed readers. The ICC value generated between the 3 readers was 0.964, indicating that inter-reader variability was small, too. Subgroup analyses showed that both intra- and inter-reader variabilities were lower for larger than for smaller plaques. Mean CVs were similar for the 5S- and 10S-methods with a RC of 4.7 μl. The RC between both methods as well as the CVs were comparatively lower for larger plaques. CONCLUSION: By implementing standardised central 3D US reading protocols and strict quality control procedures highly reliable ultrasonic re-readings of plaque images can be achieved in large multicentre trials.
format Text
id pubmed-2531085
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-25310852008-09-06 Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque Ludwig, Malte Zielinski, Tomasz Schremmer, Dieter Stumpe, Klaus O Cardiovasc Ultrasound Research BACKGROUND: Non-invasive 3-dimensional (3D) ultrasound (US) has emerged as the predominant approach for evaluating the progression of carotid atherosclerosis and its response to treatment. The aim of this study was to investigate the quality of a central reading procedure concerning plaque volume (PV), measured by 3D US in a multinational US trial. METHODS: Two data sets of 45 and 60 3D US patient images of plaques (mean PV, 71.8 and 39.8 μl, respectively) were used. PV was assessed by means of manual planimetry. The intraclass correlation coefficient (ICC) was applied to determine reader variabilities. The repeatability coefficient (RC) and the coefficient of variation (CV) were used to investigate the effect of number of slices (S) in manual planimetry and plaque size on measurement variability. RESULTS: Intra-reader variability was small as reflected by ICCs of 0.985, 0.967 and 0.969 for 3 appointed readers. The ICC value generated between the 3 readers was 0.964, indicating that inter-reader variability was small, too. Subgroup analyses showed that both intra- and inter-reader variabilities were lower for larger than for smaller plaques. Mean CVs were similar for the 5S- and 10S-methods with a RC of 4.7 μl. The RC between both methods as well as the CVs were comparatively lower for larger plaques. CONCLUSION: By implementing standardised central 3D US reading protocols and strict quality control procedures highly reliable ultrasonic re-readings of plaque images can be achieved in large multicentre trials. BioMed Central 2008-08-26 /pmc/articles/PMC2531085/ /pubmed/18727816 http://dx.doi.org/10.1186/1476-7120-6-42 Text en Copyright © 2008 Ludwig et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ludwig, Malte
Zielinski, Tomasz
Schremmer, Dieter
Stumpe, Klaus O
Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque
title Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque
title_full Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque
title_fullStr Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque
title_full_unstemmed Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque
title_short Reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque
title_sort reproducibility of 3-dimensional ultrasound readings of volume of carotid atherosclerotic plaque
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2531085/
https://www.ncbi.nlm.nih.gov/pubmed/18727816
http://dx.doi.org/10.1186/1476-7120-6-42
work_keys_str_mv AT ludwigmalte reproducibilityof3dimensionalultrasoundreadingsofvolumeofcarotidatheroscleroticplaque
AT zielinskitomasz reproducibilityof3dimensionalultrasoundreadingsofvolumeofcarotidatheroscleroticplaque
AT schremmerdieter reproducibilityof3dimensionalultrasoundreadingsofvolumeofcarotidatheroscleroticplaque
AT stumpeklauso reproducibilityof3dimensionalultrasoundreadingsofvolumeofcarotidatheroscleroticplaque