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Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population

The purpose of this study was to detect changes in coagulation and fibrinolysis of post-severe acute respiratory syndrome (SARS) Chinese patients with osteonecrosis, investigate the aetiology of post-SARS osteonecrosis (ON), and select the sensitive molecular markers for identifying the susceptible...

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Autores principales: Sun, Wei, Li, Zi–rong, Shi, Zhen–cai, Zhang, Nian–fei, Zhang, Yuan–chun
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532088/
https://www.ncbi.nlm.nih.gov/pubmed/16547717
http://dx.doi.org/10.1007/s00264-005-0067-6
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author Sun, Wei
Li, Zi–rong
Shi, Zhen–cai
Zhang, Nian–fei
Zhang, Yuan–chun
author_facet Sun, Wei
Li, Zi–rong
Shi, Zhen–cai
Zhang, Nian–fei
Zhang, Yuan–chun
author_sort Sun, Wei
collection PubMed
description The purpose of this study was to detect changes in coagulation and fibrinolysis of post-severe acute respiratory syndrome (SARS) Chinese patients with osteonecrosis, investigate the aetiology of post-SARS osteonecrosis (ON), and select the sensitive molecular markers for identifying the susceptible population. For this study, blood samples were collected from 88 patients with post-SARS ON and 52 healthy people. Activated partial thromboplastin time (APTT), protein C (PC), antithrombin III (AT–III), plasminogen activator inhibitor (PAI), activated protein C resistance (APC–R), plasminogen (PLG), von Willebrand’s factor(vWF), D–dimer (D–D), fibrinogen (Fib), and homocysteine (HCY) were examined by enzyme-linked immunosorbent assay (ELISA). We noted that blood agents of patients with ON changed obviously. APTT, PC, AT–III, PAI, APC–R, and PLG were significantly different between the two groups. Hypercoagulation and hypofibrinolysis were found in patients with post-SARS ON. Therefore, these examinations can be used to screen a population susceptible to ON. Measurements of APTT, PC, AT–III, PAI, APC–R, and PLG are sensitive blood tests for screening purposes.
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spelling pubmed-25320882008-09-08 Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population Sun, Wei Li, Zi–rong Shi, Zhen–cai Zhang, Nian–fei Zhang, Yuan–chun Int Orthop Original Paper The purpose of this study was to detect changes in coagulation and fibrinolysis of post-severe acute respiratory syndrome (SARS) Chinese patients with osteonecrosis, investigate the aetiology of post-SARS osteonecrosis (ON), and select the sensitive molecular markers for identifying the susceptible population. For this study, blood samples were collected from 88 patients with post-SARS ON and 52 healthy people. Activated partial thromboplastin time (APTT), protein C (PC), antithrombin III (AT–III), plasminogen activator inhibitor (PAI), activated protein C resistance (APC–R), plasminogen (PLG), von Willebrand’s factor(vWF), D–dimer (D–D), fibrinogen (Fib), and homocysteine (HCY) were examined by enzyme-linked immunosorbent assay (ELISA). We noted that blood agents of patients with ON changed obviously. APTT, PC, AT–III, PAI, APC–R, and PLG were significantly different between the two groups. Hypercoagulation and hypofibrinolysis were found in patients with post-SARS ON. Therefore, these examinations can be used to screen a population susceptible to ON. Measurements of APTT, PC, AT–III, PAI, APC–R, and PLG are sensitive blood tests for screening purposes. Springer-Verlag 2006-03-18 2006-06 /pmc/articles/PMC2532088/ /pubmed/16547717 http://dx.doi.org/10.1007/s00264-005-0067-6 Text en © Springer-Verlag 2006
spellingShingle Original Paper
Sun, Wei
Li, Zi–rong
Shi, Zhen–cai
Zhang, Nian–fei
Zhang, Yuan–chun
Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population
title Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population
title_full Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population
title_fullStr Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population
title_full_unstemmed Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population
title_short Changes in coagulation and fibrinolysis of post-SARS osteonecrosis in a Chinese population
title_sort changes in coagulation and fibrinolysis of post-sars osteonecrosis in a chinese population
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532088/
https://www.ncbi.nlm.nih.gov/pubmed/16547717
http://dx.doi.org/10.1007/s00264-005-0067-6
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