The triple helix: 50 years later, the outcome

Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA...

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Detalles Bibliográficos
Autores principales: Duca, Maria, Vekhoff, Pierre, Oussedik, Kahina, Halby, Ludovic, Arimondo, Paola B.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532714/
https://www.ncbi.nlm.nih.gov/pubmed/18676453
http://dx.doi.org/10.1093/nar/gkn493
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author Duca, Maria
Vekhoff, Pierre
Oussedik, Kahina
Halby, Ludovic
Arimondo, Paola B.
author_facet Duca, Maria
Vekhoff, Pierre
Oussedik, Kahina
Halby, Ludovic
Arimondo, Paola B.
author_sort Duca, Maria
collection PubMed
description Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us.
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spelling pubmed-25327142008-09-16 The triple helix: 50 years later, the outcome Duca, Maria Vekhoff, Pierre Oussedik, Kahina Halby, Ludovic Arimondo, Paola B. Nucleic Acids Res Survey and Summary Triplex-forming oligonucleotides constitute an interesting DNA sequence-specific tool that can be used to target cleaving or cross-linking agents, transcription factors or nucleases to a chosen site on the DNA. They are not only used as biotechnological tools but also to induce modifications on DNA with the aim to control gene expression, such as by site-directed mutagenesis or DNA recombination. Here, we report the state of art of the triplex-based anti-gene strategy 50 years after the discovery of such a structure, and we show the importance of the actual applications and the main challenges that we still have ahead of us. Oxford University Press 2008-09 2008-08-01 /pmc/articles/PMC2532714/ /pubmed/18676453 http://dx.doi.org/10.1093/nar/gkn493 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Survey and Summary
Duca, Maria
Vekhoff, Pierre
Oussedik, Kahina
Halby, Ludovic
Arimondo, Paola B.
The triple helix: 50 years later, the outcome
title The triple helix: 50 years later, the outcome
title_full The triple helix: 50 years later, the outcome
title_fullStr The triple helix: 50 years later, the outcome
title_full_unstemmed The triple helix: 50 years later, the outcome
title_short The triple helix: 50 years later, the outcome
title_sort triple helix: 50 years later, the outcome
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532714/
https://www.ncbi.nlm.nih.gov/pubmed/18676453
http://dx.doi.org/10.1093/nar/gkn493
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