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N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis
The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532733/ https://www.ncbi.nlm.nih.gov/pubmed/18689861 http://dx.doi.org/10.1093/nar/gkn504 |
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author | Liu, Na Wang, Lifeng Li, Xia Yang, Qi Liu, Xinping Zhang, Jing Zhang, Jian Wu, Yousheng Ji, Shaoping Zhang, Yingqi Yang, Angang Han, Hua Yao, Libo |
author_facet | Liu, Na Wang, Lifeng Li, Xia Yang, Qi Liu, Xinping Zhang, Jing Zhang, Jian Wu, Yousheng Ji, Shaoping Zhang, Yingqi Yang, Angang Han, Hua Yao, Libo |
author_sort | Liu, Na |
collection | PubMed |
description | The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (NDRG2) is a new target gene that is regulated by p53. NDRG2 mRNA and protein levels can be upregulated in a p53-dependent manner. The first intron of the NDRG2 gene contains a site that binds p53 directly and mediates wild-type p53-dependent transactivation. In addition, silencing of NDRG2 attenuates p53-mediated apoptosis, whereas overexpression of NDRG2 suppresses tumor cell growth, regardless of the presence or absence of p53. Our results indicate that NDRG2 is a novel p53-inducible target that is involved in the p53-mediated apoptosis pathway. |
format | Text |
id | pubmed-2532733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25327332008-09-16 N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis Liu, Na Wang, Lifeng Li, Xia Yang, Qi Liu, Xinping Zhang, Jing Zhang, Jian Wu, Yousheng Ji, Shaoping Zhang, Yingqi Yang, Angang Han, Hua Yao, Libo Nucleic Acids Res Molecular Biology The tumor suppressor, p53, is a transcription factor which can modulate the transcription of a number of target genes that are involved in cell-cycle arrest and apoptosis. However, the apoptotic pathway mediated by p53 is not fully understood. Here, we showed that N-Myc downstream-regulated gene 2 (NDRG2) is a new target gene that is regulated by p53. NDRG2 mRNA and protein levels can be upregulated in a p53-dependent manner. The first intron of the NDRG2 gene contains a site that binds p53 directly and mediates wild-type p53-dependent transactivation. In addition, silencing of NDRG2 attenuates p53-mediated apoptosis, whereas overexpression of NDRG2 suppresses tumor cell growth, regardless of the presence or absence of p53. Our results indicate that NDRG2 is a novel p53-inducible target that is involved in the p53-mediated apoptosis pathway. Oxford University Press 2008-09 2008-08-09 /pmc/articles/PMC2532733/ /pubmed/18689861 http://dx.doi.org/10.1093/nar/gkn504 Text en © 2008 The Author(s) http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Molecular Biology Liu, Na Wang, Lifeng Li, Xia Yang, Qi Liu, Xinping Zhang, Jing Zhang, Jian Wu, Yousheng Ji, Shaoping Zhang, Yingqi Yang, Angang Han, Hua Yao, Libo N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis |
title | N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis |
title_full | N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis |
title_fullStr | N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis |
title_full_unstemmed | N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis |
title_short | N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis |
title_sort | n-myc downstream-regulated gene 2 is involved in p53-mediated apoptosis |
topic | Molecular Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532733/ https://www.ncbi.nlm.nih.gov/pubmed/18689861 http://dx.doi.org/10.1093/nar/gkn504 |
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