Protein Isoaspartate Methyltransferase Prevents Apoptosis Induced by Oxidative Stress in Endothelial Cells: Role of Bcl-X(l) Deamidation and Methylation

BACKGROUND: Natural proteins undergo in vivo spontaneous post-biosynthetic deamidation of specific asparagine residues with isoaspartyl formation. Deamidated-isomerized molecules are both structurally and functionally altered. The enzyme isoaspartyl protein carboxyl-O-methyltransferase (PCMT; EC 2.1...

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Detalles Bibliográficos
Autores principales: Cimmino, Amelia, Capasso, Rosanna, Muller, Fabbri, Sambri, Irene, Masella, Lucia, Raimo, Marianna, De Bonis, Maria Luigia, D'Angelo, Stefania, Zappia, Vincenzo, Galletti, Patrizia, Ingrosso, Diego
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2532751/
https://www.ncbi.nlm.nih.gov/pubmed/18806875
http://dx.doi.org/10.1371/journal.pone.0003258

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