Simulation of developmental changes in action potentials with ventricular cell models

During cardiomyocyte development, early embryonic ventricular cells show spontaneous activity that disappears at a later stage. Dramatic changes in action potential are mediated by developmental changes in individual ionic currents. Hence, reconstruction of the individual ionic currents into an inte...

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Detalles Bibliográficos
Autores principales: Itoh, Hitomi, Naito, Yasuhiro, Tomita, Masaru
Formato: Texto
Lenguaje:English
Publicado: Kluwer Academic Publishers 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533146/
https://www.ncbi.nlm.nih.gov/pubmed/19003434
http://dx.doi.org/10.1007/s11693-006-9002-4
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author Itoh, Hitomi
Naito, Yasuhiro
Tomita, Masaru
author_facet Itoh, Hitomi
Naito, Yasuhiro
Tomita, Masaru
author_sort Itoh, Hitomi
collection PubMed
description During cardiomyocyte development, early embryonic ventricular cells show spontaneous activity that disappears at a later stage. Dramatic changes in action potential are mediated by developmental changes in individual ionic currents. Hence, reconstruction of the individual ionic currents into an integrated mathematical model would lead to a better understanding of cardiomyocyte development. To simulate the action potential of the rodent ventricular cell at three representative developmental stages, quantitative changes in the ionic currents, pumps, exchangers, and sarcoplasmic reticulum (SR) Ca(2+) kinetics were represented as relative activities, which were multiplied by conductance or conversion factors for individual ionic systems. The simulated action potential of the early embryonic ventricular cell model exhibited spontaneous activity, which ceased in the simulated action potential of the late embryonic and neonatal ventricular cell models. The simulations with our models were able to reproduce action potentials that were consistent with the reported characteristics of the cells in vitro. The action potential of rodent ventricular cells at different developmental stages can be reproduced with common sets of mathematical equations by multiplying conductance or conversion factors for ionic currents, pumps, exchangers, and SR Ca(2+) kinetics by relative activities.
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spelling pubmed-25331462008-10-01 Simulation of developmental changes in action potentials with ventricular cell models Itoh, Hitomi Naito, Yasuhiro Tomita, Masaru Syst Synth Biol Research Article During cardiomyocyte development, early embryonic ventricular cells show spontaneous activity that disappears at a later stage. Dramatic changes in action potential are mediated by developmental changes in individual ionic currents. Hence, reconstruction of the individual ionic currents into an integrated mathematical model would lead to a better understanding of cardiomyocyte development. To simulate the action potential of the rodent ventricular cell at three representative developmental stages, quantitative changes in the ionic currents, pumps, exchangers, and sarcoplasmic reticulum (SR) Ca(2+) kinetics were represented as relative activities, which were multiplied by conductance or conversion factors for individual ionic systems. The simulated action potential of the early embryonic ventricular cell model exhibited spontaneous activity, which ceased in the simulated action potential of the late embryonic and neonatal ventricular cell models. The simulations with our models were able to reproduce action potentials that were consistent with the reported characteristics of the cells in vitro. The action potential of rodent ventricular cells at different developmental stages can be reproduced with common sets of mathematical equations by multiplying conductance or conversion factors for ionic currents, pumps, exchangers, and SR Ca(2+) kinetics by relative activities. Kluwer Academic Publishers 2006-11-16 2007-03 /pmc/articles/PMC2533146/ /pubmed/19003434 http://dx.doi.org/10.1007/s11693-006-9002-4 Text en © Springer Science + Business Media B.V. 2006
spellingShingle Research Article
Itoh, Hitomi
Naito, Yasuhiro
Tomita, Masaru
Simulation of developmental changes in action potentials with ventricular cell models
title Simulation of developmental changes in action potentials with ventricular cell models
title_full Simulation of developmental changes in action potentials with ventricular cell models
title_fullStr Simulation of developmental changes in action potentials with ventricular cell models
title_full_unstemmed Simulation of developmental changes in action potentials with ventricular cell models
title_short Simulation of developmental changes in action potentials with ventricular cell models
title_sort simulation of developmental changes in action potentials with ventricular cell models
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533146/
https://www.ncbi.nlm.nih.gov/pubmed/19003434
http://dx.doi.org/10.1007/s11693-006-9002-4
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