The HTLV-1 Tax interactome

The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions...

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Detalles Bibliográficos
Autores principales: Boxus, Mathieu, Twizere, Jean-Claude, Legros, Sébastien, Dewulf, Jean-François, Kettmann, Richard, Willems, Luc
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533353/
https://www.ncbi.nlm.nih.gov/pubmed/18702816
http://dx.doi.org/10.1186/1742-4690-5-76
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author Boxus, Mathieu
Twizere, Jean-Claude
Legros, Sébastien
Dewulf, Jean-François
Kettmann, Richard
Willems, Luc
author_facet Boxus, Mathieu
Twizere, Jean-Claude
Legros, Sébastien
Dewulf, Jean-François
Kettmann, Richard
Willems, Luc
author_sort Boxus, Mathieu
collection PubMed
description The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far.
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spelling pubmed-25333532008-09-11 The HTLV-1 Tax interactome Boxus, Mathieu Twizere, Jean-Claude Legros, Sébastien Dewulf, Jean-François Kettmann, Richard Willems, Luc Retrovirology Review The Tax1 oncoprotein encoded by Human T-lymphotropic virus type I is a major determinant of viral persistence and pathogenesis. Tax1 affects a wide variety of cellular signalling pathways leading to transcriptional activation, proliferation and ultimately transformation. To carry out these functions, Tax1 interacts with and modulates activity of a number of cellular proteins. In this review, we summarize the present knowledge of the Tax1 interactome and propose a rationale for the broad range of cellular proteins identified so far. BioMed Central 2008-08-14 /pmc/articles/PMC2533353/ /pubmed/18702816 http://dx.doi.org/10.1186/1742-4690-5-76 Text en Copyright © 2008 Boxus et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Boxus, Mathieu
Twizere, Jean-Claude
Legros, Sébastien
Dewulf, Jean-François
Kettmann, Richard
Willems, Luc
The HTLV-1 Tax interactome
title The HTLV-1 Tax interactome
title_full The HTLV-1 Tax interactome
title_fullStr The HTLV-1 Tax interactome
title_full_unstemmed The HTLV-1 Tax interactome
title_short The HTLV-1 Tax interactome
title_sort htlv-1 tax interactome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533353/
https://www.ncbi.nlm.nih.gov/pubmed/18702816
http://dx.doi.org/10.1186/1742-4690-5-76
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