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Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57(KIP2 )and Cdk2
BACKGROUND: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in genes PKD1 and PKD2 account for nearly all cases of ADPKD. Increased cell prolifer...
Autores principales: | Felekkis, Kyriacos N, Koupepidou, Panayiota, Kastanos, Evdokia, Witzgall, Ralph, Bai, Chang-Xi, Li, Li, Tsiokas, Leonidas, Gretz, Norbert, Deltas, Constantinos |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533650/ https://www.ncbi.nlm.nih.gov/pubmed/18721488 http://dx.doi.org/10.1186/1471-2369-9-10 |
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