Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme

Linoleic acid (LA) preincubated with cyclooxygenase (COX)-1 or -2 inhibited prostaglandin (PG) formation from arachidonic acid (AA) catalyzed by the respective enzyme, but LA without the preincubation did not. 13S-Hydroperoxy-9Z,11E-octadecadienoic acid (13-HPODE) a hydroperoxy adduct of LA inhibite...

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Autores principales: Fujimoto, Yohko, Yonemura, Toshimitsu, Sakuma, Satoru
Formato: Texto
Lenguaje:English
Publicado: the Society for Free Radical Research Japan 2008
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533720/
https://www.ncbi.nlm.nih.gov/pubmed/18818754
http://dx.doi.org/10.3164/jcbn.2008047
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author Fujimoto, Yohko
Yonemura, Toshimitsu
Sakuma, Satoru
author_facet Fujimoto, Yohko
Yonemura, Toshimitsu
Sakuma, Satoru
author_sort Fujimoto, Yohko
collection PubMed
description Linoleic acid (LA) preincubated with cyclooxygenase (COX)-1 or -2 inhibited prostaglandin (PG) formation from arachidonic acid (AA) catalyzed by the respective enzyme, but LA without the preincubation did not. 13S-Hydroperoxy-9Z,11E-octadecadienoic acid (13-HPODE) a hydroperoxy adduct of LA inhibited PG formation catalyzed by COX-1 or -2. 13S-Hydroxy-9Z,11E-octadecadienoic acid had no effect on both COX-1 and -2 activities. These results suggest that 13-HPODE which is preformed from LA by COX reaction under normal physiological conditions can be a basal suppressor of PG formation from AA.
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spelling pubmed-25337202008-09-25 Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme Fujimoto, Yohko Yonemura, Toshimitsu Sakuma, Satoru J Clin Biochem Nutr Original Article Linoleic acid (LA) preincubated with cyclooxygenase (COX)-1 or -2 inhibited prostaglandin (PG) formation from arachidonic acid (AA) catalyzed by the respective enzyme, but LA without the preincubation did not. 13S-Hydroperoxy-9Z,11E-octadecadienoic acid (13-HPODE) a hydroperoxy adduct of LA inhibited PG formation catalyzed by COX-1 or -2. 13S-Hydroxy-9Z,11E-octadecadienoic acid had no effect on both COX-1 and -2 activities. These results suggest that 13-HPODE which is preformed from LA by COX reaction under normal physiological conditions can be a basal suppressor of PG formation from AA. the Society for Free Radical Research Japan 2008-09 2008-08-30 /pmc/articles/PMC2533720/ /pubmed/18818754 http://dx.doi.org/10.3164/jcbn.2008047 Text en Copyright © 2008 JCBN This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Fujimoto, Yohko
Yonemura, Toshimitsu
Sakuma, Satoru
Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme
title Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme
title_full Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme
title_fullStr Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme
title_full_unstemmed Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme
title_short Role of Linoleic Acid Hydroperoxide Preformed by Cyclooxygenase-1 or -2 on the Regulation of Prostaglandin Formation from Arachidonic Acid by the Respective Enzyme
title_sort role of linoleic acid hydroperoxide preformed by cyclooxygenase-1 or -2 on the regulation of prostaglandin formation from arachidonic acid by the respective enzyme
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533720/
https://www.ncbi.nlm.nih.gov/pubmed/18818754
http://dx.doi.org/10.3164/jcbn.2008047
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