Regulatory ATPase Sites of Cytoplasmic Dynein Affect Processivity and Force Generation

The heavy chain of cytoplasmic dynein contains four nucleotide-binding domains referred to as AAA1–AAA4, with the first domain (AAA1) being the main ATP hydrolytic site. Although previous studies have proposed regulatory roles for AAA3 and AAA4, the role of ATP hydrolysis at these sites remains elus...

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Detalles Bibliográficos
Autores principales: Cho, Carol, Reck-Peterson, Samara L., Vale, Ronald D.
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2008
Materias:
Molecular Basis of Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533788/
https://www.ncbi.nlm.nih.gov/pubmed/18650442
http://dx.doi.org/10.1074/jbc.M802951200

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533788/
https://www.ncbi.nlm.nih.gov/pubmed/18650442
http://dx.doi.org/10.1074/jbc.M802951200

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