Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery

[Image: see text] There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. T...

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Autores principales: Bugni, Tim S., Richards, Burt, Bhoite, Leen, Cimbora, Daniel, Harper, Mary Kay, Ireland, Chris M.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2008
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533854/
https://www.ncbi.nlm.nih.gov/pubmed/18505284
http://dx.doi.org/10.1021/np800184g
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author Bugni, Tim S.
Richards, Burt
Bhoite, Leen
Cimbora, Daniel
Harper, Mary Kay
Ireland, Chris M.
author_facet Bugni, Tim S.
Richards, Burt
Bhoite, Leen
Cimbora, Daniel
Harper, Mary Kay
Ireland, Chris M.
author_sort Bugni, Tim S.
collection PubMed
description [Image: see text] There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.
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spelling pubmed-25338542009-03-20 Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery Bugni, Tim S. Richards, Burt Bhoite, Leen Cimbora, Daniel Harper, Mary Kay Ireland, Chris M. J Nat Prod [Image: see text] There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells. American Chemical Society and American Society of Pharmacognosy 2008-05-28 2008-06-27 /pmc/articles/PMC2533854/ /pubmed/18505284 http://dx.doi.org/10.1021/np800184g Text en Copyright © 2008 American Chemical Society and American Society of Pharmacognosy http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.
spellingShingle Bugni, Tim S.
Richards, Burt
Bhoite, Leen
Cimbora, Daniel
Harper, Mary Kay
Ireland, Chris M.
Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
title Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
title_full Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
title_fullStr Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
title_full_unstemmed Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
title_short Marine Natural Product Libraries for High-Throughput Screening and Rapid Drug Discovery
title_sort marine natural product libraries for high-throughput screening and rapid drug discovery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533854/
https://www.ncbi.nlm.nih.gov/pubmed/18505284
http://dx.doi.org/10.1021/np800184g
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