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Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones
BACKGROUND: Since 1999, several articles have been published on genome-wide and/or proteome-wide response after exposure to radiofrequency (RF) fields whose signal and intensities were similar to or typical of those of currently used mobile telephones. These studies were performed using powerful hig...
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Formato: | Texto |
Lenguaje: | English |
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National Institute of Environmental Health Sciences
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535611/ https://www.ncbi.nlm.nih.gov/pubmed/18795152 http://dx.doi.org/10.1289/ehp.11279 |
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author | Vanderstraeten, Jacques Verschaeve, Luc |
author_facet | Vanderstraeten, Jacques Verschaeve, Luc |
author_sort | Vanderstraeten, Jacques |
collection | PubMed |
description | BACKGROUND: Since 1999, several articles have been published on genome-wide and/or proteome-wide response after exposure to radiofrequency (RF) fields whose signal and intensities were similar to or typical of those of currently used mobile telephones. These studies were performed using powerful high-throughput screening techniques (HTSTs) of transcriptomics and/or proteomics, which allow for the simultaneous screening of the expression of thousands of genes or proteins. OBJECTIVES: We reviewed these HTST-based studies and compared the results with currently accepted concepts about the effects of RF fields on gene expression. In this article we also discuss these last in light of the recent concept of microwave-assisted chemistry. DISCUSSION: To date, the results of HTST-based studies of transcriptomics and/or proteomics after exposure to RF fields relevant to human exposure are still inconclusive, as most of the positive reports are flawed by methodologic imperfections or shortcomings. In addition, when positive findings were reported, no precise response pattern could be identified in a reproducible way. In particular, results from HTST studies tend to exclude the role of a cell stressor for exposure to RF fields at nonthermal intensities. However, on the basis of lessons from microwave-assisted chemistry, we can assume that RF fields might affect heat-sensitive gene or protein expression to an extent larger than would be predicted from temperature change only. But in all likelihood, this would concern intensities higher than those relevant to usual human exposure. CONCLUSIONS: The precise role of transcriptomics and proteomics in the screening of bioeffects from exposure to RF fields from mobile phones is still uncertain in view of the lack of positively identified phenotypic change and the lack of theoretical, as well as experimental, arguments for specific gene and/or protein response patterns after this kind of exposure. |
format | Text |
id | pubmed-2535611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | National Institute of Environmental Health Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-25356112008-09-15 Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones Vanderstraeten, Jacques Verschaeve, Luc Environ Health Perspect Commentary BACKGROUND: Since 1999, several articles have been published on genome-wide and/or proteome-wide response after exposure to radiofrequency (RF) fields whose signal and intensities were similar to or typical of those of currently used mobile telephones. These studies were performed using powerful high-throughput screening techniques (HTSTs) of transcriptomics and/or proteomics, which allow for the simultaneous screening of the expression of thousands of genes or proteins. OBJECTIVES: We reviewed these HTST-based studies and compared the results with currently accepted concepts about the effects of RF fields on gene expression. In this article we also discuss these last in light of the recent concept of microwave-assisted chemistry. DISCUSSION: To date, the results of HTST-based studies of transcriptomics and/or proteomics after exposure to RF fields relevant to human exposure are still inconclusive, as most of the positive reports are flawed by methodologic imperfections or shortcomings. In addition, when positive findings were reported, no precise response pattern could be identified in a reproducible way. In particular, results from HTST studies tend to exclude the role of a cell stressor for exposure to RF fields at nonthermal intensities. However, on the basis of lessons from microwave-assisted chemistry, we can assume that RF fields might affect heat-sensitive gene or protein expression to an extent larger than would be predicted from temperature change only. But in all likelihood, this would concern intensities higher than those relevant to usual human exposure. CONCLUSIONS: The precise role of transcriptomics and proteomics in the screening of bioeffects from exposure to RF fields from mobile phones is still uncertain in view of the lack of positively identified phenotypic change and the lack of theoretical, as well as experimental, arguments for specific gene and/or protein response patterns after this kind of exposure. National Institute of Environmental Health Sciences 2008-09 2008-05-13 /pmc/articles/PMC2535611/ /pubmed/18795152 http://dx.doi.org/10.1289/ehp.11279 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
spellingShingle | Commentary Vanderstraeten, Jacques Verschaeve, Luc Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones |
title | Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones |
title_full | Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones |
title_fullStr | Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones |
title_full_unstemmed | Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones |
title_short | Gene and Protein Expression following Exposure to Radiofrequency Fields from Mobile Phones |
title_sort | gene and protein expression following exposure to radiofrequency fields from mobile phones |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535611/ https://www.ncbi.nlm.nih.gov/pubmed/18795152 http://dx.doi.org/10.1289/ehp.11279 |
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