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Bone Mineral Density Changes in Relation to Environmental PCB Exposure

BACKGROUND: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. OBJECTIVES: The aim of this study was to investigate whether organo...

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Autores principales: Hodgson, Susan, Thomas, Laura, Fattore, Elena, Lind, P. Monica, Alfven, Tobias, Hellström, Lennart, Håkansson, Helen, Carubelli, Grazia, Fanelli, Roberto, Jarup, Lars
Formato: Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535616/
https://www.ncbi.nlm.nih.gov/pubmed/18795157
http://dx.doi.org/10.1289/ehp.11107
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author Hodgson, Susan
Thomas, Laura
Fattore, Elena
Lind, P. Monica
Alfven, Tobias
Hellström, Lennart
Håkansson, Helen
Carubelli, Grazia
Fanelli, Roberto
Jarup, Lars
author_facet Hodgson, Susan
Thomas, Laura
Fattore, Elena
Lind, P. Monica
Alfven, Tobias
Hellström, Lennart
Håkansson, Helen
Carubelli, Grazia
Fanelli, Roberto
Jarup, Lars
author_sort Hodgson, Susan
collection PubMed
description BACKGROUND: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. OBJECTIVES: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60–81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). METHODS: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p′-dichloro-phenyldichloroethylene (p,p′-DDE). RESULTS: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than −1) was 1.06 (95% confidence interval, 1.01–1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. CONCLUSIONS: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD.
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spelling pubmed-25356162008-09-15 Bone Mineral Density Changes in Relation to Environmental PCB Exposure Hodgson, Susan Thomas, Laura Fattore, Elena Lind, P. Monica Alfven, Tobias Hellström, Lennart Håkansson, Helen Carubelli, Grazia Fanelli, Roberto Jarup, Lars Environ Health Perspect Research BACKGROUND: Bone toxicity has been linked to organochlorine exposure following a few notable poisoning incidents, but epidemiologic studies in populations with environmental organochlorine exposure have yielded inconsistent results. OBJECTIVES: The aim of this study was to investigate whether organochlorine exposure was associated with bone mineral density (BMD) in a population 60–81 years of age (154 males, 167 females) living near the Baltic coast, close to a river contaminated by polychlorinated biphenyls (PCBs). METHODS: We measured forearm BMD in participants using dual energy X-ray absorptiometry; and we assessed low BMD using age- and sex-standardized Z-scores. We analyzed blood samples for five dioxin-like PCBs, the three most abundant non-dioxin-like PCBs, and p,p′-dichloro-phenyldichloroethylene (p,p′-DDE). RESULTS: In males, dioxin-like chlorobiphenyl (CB)-118 was negatively associated with BMD; the odds ratio for low BMD (Z-score less than −1) was 1.06 (95% confidence interval, 1.01–1.12) per 10 pg/mL CB-118. The sum of the three most abundant non-dioxin-like PCBs was positively associated with BMD, but not with a decreased risk of low BMD. In females, CB-118 was positively associated with BMD, but this congener did not influence the risk of low BMD in women. CONCLUSIONS: Environmental organochlorine exposures experienced by this population sample since the 1930s in Sweden may have been sufficient to result in sex-specific changes in BMD. National Institute of Environmental Health Sciences 2008-09 2008-05-16 /pmc/articles/PMC2535616/ /pubmed/18795157 http://dx.doi.org/10.1289/ehp.11107 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Hodgson, Susan
Thomas, Laura
Fattore, Elena
Lind, P. Monica
Alfven, Tobias
Hellström, Lennart
Håkansson, Helen
Carubelli, Grazia
Fanelli, Roberto
Jarup, Lars
Bone Mineral Density Changes in Relation to Environmental PCB Exposure
title Bone Mineral Density Changes in Relation to Environmental PCB Exposure
title_full Bone Mineral Density Changes in Relation to Environmental PCB Exposure
title_fullStr Bone Mineral Density Changes in Relation to Environmental PCB Exposure
title_full_unstemmed Bone Mineral Density Changes in Relation to Environmental PCB Exposure
title_short Bone Mineral Density Changes in Relation to Environmental PCB Exposure
title_sort bone mineral density changes in relation to environmental pcb exposure
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535616/
https://www.ncbi.nlm.nih.gov/pubmed/18795157
http://dx.doi.org/10.1289/ehp.11107
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