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Cross-Species Differential Plasma Protein Binding of MBX-102/JNJ39659100: A Novel PPAR-γ Agonist

Drug binding to plasma proteins restricts their free and active concentrations, thereby affecting their pharmacokinetic properties. Species differences in plasma protein levels complicate the understanding of interspecies pharmacodynamic and toxicological effects. MBX-102 acid/JNJ39659100 is a novel...

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Detalles Bibliográficos
Autores principales:	Clarke, Holly J., Gregoire, Francine, Ma, Fang, Martin, Robert, Zhao, Spring, Lavan, Brian E.
Formato:	Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2535826/ https://www.ncbi.nlm.nih.gov/pubmed/18815616 http://dx.doi.org/10.1155/2008/465715

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