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Efficient p-value estimation in massively parallel testing problems
We present a new method to efficiently estimate very large numbers of p-values using empirically constructed null distributions of a test statistic. The need to evaluate a very large number of p-values is increasingly common with modern genomic data, and when interaction effects are of interest, the...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536722/ https://www.ncbi.nlm.nih.gov/pubmed/18304995 http://dx.doi.org/10.1093/biostatistics/kxm053 |