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Utility of a single adjusting compartment: a novel methodology for whole body physiologically-based pharmacokinetic modelling

BACKGROUND: There are various methods for predicting human pharmacokinetics. Among these, a whole body physiologically-based pharmacokinetic (WBPBPK) model is useful because it gives a mechanistic description. However, WBPBPK models cannot predict human pharmacokinetics with enough precision. This s...

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Detalles Bibliográficos
Autores principales:	Ando, Hirotaka, Izawa, Shigeru, Hori, Wataru, Nakagawa, Ippei
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542356/ https://www.ncbi.nlm.nih.gov/pubmed/18687151 http://dx.doi.org/10.1186/1742-4682-5-19

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