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Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population
Background. The survival of human immunodeficiency virus (HIV)-infected patients has increased significantly since the introduction of combination antiretroviral therapy, leading to the development of important long-term complications including cardiovascular disease (CVD) and renal disease. Microal...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Oxford University Press
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542409/ https://www.ncbi.nlm.nih.gov/pubmed/18469311 http://dx.doi.org/10.1093/ndt/gfn236 |
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author | Baekken, Morten Os, Ingrid Sandvik, Leiv Oektedalen, Olav |
author_facet | Baekken, Morten Os, Ingrid Sandvik, Leiv Oektedalen, Olav |
author_sort | Baekken, Morten |
collection | PubMed |
description | Background. The survival of human immunodeficiency virus (HIV)-infected patients has increased significantly since the introduction of combination antiretroviral therapy, leading to the development of important long-term complications including cardiovascular disease (CVD) and renal disease. Microalbuminuria, an indicator of glomerular injury, is associated with an increased risk of progressive renal deterioration, CVD and mortality. However, the prevalence of microalbuminuria has barely been investigated in HIV-infected individuals. Methods. Based on three prospective urine samples in an unselected nonhypertensive, nondiabetic HIV-positive cohort (n = 495), we analysed the prevalence of microalbuminuria and compared the Caucasian share with that of a nonhypertensive, nondiabetic population-based control group (n = 2091). Significant predictors for microalbuminuria were analysed within the HIV-positive cohort. Results. The prevalence of microalbuminuria was 8.7% in the HIV-infected cohort, which is three to five times higher than that in the general population. HIV-infected patients with microalbuminuria were older, and had higher blood pressure, longer duration of HIV infection, higher serum beta 2-microglobulin, higher serum creatinine and a reduced glomerular filtration rate of ≤90 mL/min, compared with those with normal albumin excretion. In multivariate analysis, systolic blood pressure, serum beta 2-microglobulin and duration of HIV infection were found to be independent predictors of microalbuminuria. Conclusions. Our findings indicate that in addition to haemodynamic effects, inflammatory activity may be implicated as a cause of the development of microalbuminuria. With respect to the increasing risk of developing CVD or renal diseases and mortality, the high prevalence of microalbuminuria in HIV-infected individuals warrants special attention. |
format | Text |
id | pubmed-2542409 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-25424092009-02-25 Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population Baekken, Morten Os, Ingrid Sandvik, Leiv Oektedalen, Olav Nephrol Dial Transplant Clinical Nephrology Background. The survival of human immunodeficiency virus (HIV)-infected patients has increased significantly since the introduction of combination antiretroviral therapy, leading to the development of important long-term complications including cardiovascular disease (CVD) and renal disease. Microalbuminuria, an indicator of glomerular injury, is associated with an increased risk of progressive renal deterioration, CVD and mortality. However, the prevalence of microalbuminuria has barely been investigated in HIV-infected individuals. Methods. Based on three prospective urine samples in an unselected nonhypertensive, nondiabetic HIV-positive cohort (n = 495), we analysed the prevalence of microalbuminuria and compared the Caucasian share with that of a nonhypertensive, nondiabetic population-based control group (n = 2091). Significant predictors for microalbuminuria were analysed within the HIV-positive cohort. Results. The prevalence of microalbuminuria was 8.7% in the HIV-infected cohort, which is three to five times higher than that in the general population. HIV-infected patients with microalbuminuria were older, and had higher blood pressure, longer duration of HIV infection, higher serum beta 2-microglobulin, higher serum creatinine and a reduced glomerular filtration rate of ≤90 mL/min, compared with those with normal albumin excretion. In multivariate analysis, systolic blood pressure, serum beta 2-microglobulin and duration of HIV infection were found to be independent predictors of microalbuminuria. Conclusions. Our findings indicate that in addition to haemodynamic effects, inflammatory activity may be implicated as a cause of the development of microalbuminuria. With respect to the increasing risk of developing CVD or renal diseases and mortality, the high prevalence of microalbuminuria in HIV-infected individuals warrants special attention. Oxford University Press 2008-10 2008-05-09 /pmc/articles/PMC2542409/ /pubmed/18469311 http://dx.doi.org/10.1093/ndt/gfn236 Text en © The Author [2008]. http://creativecommons.org/licenses/by-nc/2.0/uk/ The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org |
spellingShingle | Clinical Nephrology Baekken, Morten Os, Ingrid Sandvik, Leiv Oektedalen, Olav Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population |
title | Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population |
title_full | Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population |
title_fullStr | Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population |
title_full_unstemmed | Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population |
title_short | Microalbuminuria associated with indicators of inflammatory activity in an HIV-positive population |
title_sort | microalbuminuria associated with indicators of inflammatory activity in an hiv-positive population |
topic | Clinical Nephrology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542409/ https://www.ncbi.nlm.nih.gov/pubmed/18469311 http://dx.doi.org/10.1093/ndt/gfn236 |
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