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PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion

Today, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARγ activators mediate their antimigratory and a...

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Detalles Bibliográficos
Autores principales: Seufert, Sebastian, Coras, Roland, Tränkle, Christian, Zlotos, Darius P., Blümcke, Ingmar, Tatenhorst, Lars, Heneka, Michael T., Hahnen, Eric
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542841/
https://www.ncbi.nlm.nih.gov/pubmed/18815619
http://dx.doi.org/10.1155/2008/513943
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author Seufert, Sebastian
Coras, Roland
Tränkle, Christian
Zlotos, Darius P.
Blümcke, Ingmar
Tatenhorst, Lars
Heneka, Michael T.
Hahnen, Eric
author_facet Seufert, Sebastian
Coras, Roland
Tränkle, Christian
Zlotos, Darius P.
Blümcke, Ingmar
Tatenhorst, Lars
Heneka, Michael T.
Hahnen, Eric
author_sort Seufert, Sebastian
collection PubMed
description Today, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARγ activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARγ inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARγ independent manner.
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spelling pubmed-25428412008-09-24 PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion Seufert, Sebastian Coras, Roland Tränkle, Christian Zlotos, Darius P. Blümcke, Ingmar Tatenhorst, Lars Heneka, Michael T. Hahnen, Eric PPAR Res Review Article Today, there is increasing evidence that PPARγ agonists, including thiazolidinediones (TDZs) and nonthiazolidinediones, block the motility and invasiveness of glioma cells and other highly migratory tumor entities. However, the mechanism(s) by which PPARγ activators mediate their antimigratory and anti-invasive properties remains elusive. This letter gives a short review on the debate and adds to the current knowledge by applying a PPARγ inactive derivative of the TDZ troglitazone (Rezulin) which potently counteracts experimental glioma progression in a PPARγ independent manner. Hindawi Publishing Corporation 2008 2008-09-14 /pmc/articles/PMC2542841/ /pubmed/18815619 http://dx.doi.org/10.1155/2008/513943 Text en Copyright © 2008 Sebastian Seufert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Seufert, Sebastian
Coras, Roland
Tränkle, Christian
Zlotos, Darius P.
Blümcke, Ingmar
Tatenhorst, Lars
Heneka, Michael T.
Hahnen, Eric
PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
title PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
title_full PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
title_fullStr PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
title_full_unstemmed PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
title_short PPAR Gamma Activators: Off-Target Against Glioma Cell Migration and Brain Invasion
title_sort ppar gamma activators: off-target against glioma cell migration and brain invasion
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542841/
https://www.ncbi.nlm.nih.gov/pubmed/18815619
http://dx.doi.org/10.1155/2008/513943
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