Docking of molecules identified in bioactive medicinal plants extracts into the p50 NF-kappaB transcription factor: correlation with inhibition of NF-kappaB/DNA interactions and inhibitory effects on IL-8 gene expression

BACKGROUND: The transcription factor NF-kappaB is a very interesting target molecule for the design on anti-tumor, anti-inflammatory and pro-apoptotic drugs. However, the application of the widely-used molecular docking computational method for the virtual screening of chemical libraries on NF-kappa...

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Detalles Bibliográficos
Autores principales: Piccagli, Laura, Fabbri, Enrica, Borgatti, Monica, Bezzerri, Valentino, Mancini, Irene, Nicolis, Elena, Dechecchi, Maria C, Lampronti, Ilaria, Cabrini, Giulio, Gambari, Roberto
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543017/
https://www.ncbi.nlm.nih.gov/pubmed/18768082
http://dx.doi.org/10.1186/1472-6807-8-38

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