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The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome

BACKGROUND: To evaluate the relationship between endometrial thickness on day of human chorionic gonadotrophin administration (hCG) and pregnancy outcome in a large number of consecutive in vitro fertilization and embryo transfer (IVF-ET) cycles. METHODS: A retrospective cohort study including all p...

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Autores principales: Al-Ghamdi, Ahlam, Coskun, Serdar, Al-Hassan, Saad, Al-Rejjal, Rafat, Awartani, Khalid
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543019/
https://www.ncbi.nlm.nih.gov/pubmed/18764940
http://dx.doi.org/10.1186/1477-7827-6-37
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author Al-Ghamdi, Ahlam
Coskun, Serdar
Al-Hassan, Saad
Al-Rejjal, Rafat
Awartani, Khalid
author_facet Al-Ghamdi, Ahlam
Coskun, Serdar
Al-Hassan, Saad
Al-Rejjal, Rafat
Awartani, Khalid
author_sort Al-Ghamdi, Ahlam
collection PubMed
description BACKGROUND: To evaluate the relationship between endometrial thickness on day of human chorionic gonadotrophin administration (hCG) and pregnancy outcome in a large number of consecutive in vitro fertilization and embryo transfer (IVF-ET) cycles. METHODS: A retrospective cohort study including all patients who had IVF-ET from January 2003–December 2005 conducted at a tertiary center. RESULTS: A total of 2464 cycles were analysed. Pregnancy rate (PR) was 35.8%. PR increased linearly (r = 0.864) from 29.4% among patients with a lining of less than or equal to 6 mm, to 44.4% among patients with a lining of greater than or equal to 17 mm. ROC showed that endometrial thickness is not a good predictor of PR, so a definite cut-off value could not be established (AUC = 0.55). CONCLUSION: There is a positive linear relationship between the endometrial thickness measured on the day of hCG injection and PR, and is independent of other variables. Hence aiming for a thicker endometrium should be considered.
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spelling pubmed-25430192008-09-19 The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome Al-Ghamdi, Ahlam Coskun, Serdar Al-Hassan, Saad Al-Rejjal, Rafat Awartani, Khalid Reprod Biol Endocrinol Research BACKGROUND: To evaluate the relationship between endometrial thickness on day of human chorionic gonadotrophin administration (hCG) and pregnancy outcome in a large number of consecutive in vitro fertilization and embryo transfer (IVF-ET) cycles. METHODS: A retrospective cohort study including all patients who had IVF-ET from January 2003–December 2005 conducted at a tertiary center. RESULTS: A total of 2464 cycles were analysed. Pregnancy rate (PR) was 35.8%. PR increased linearly (r = 0.864) from 29.4% among patients with a lining of less than or equal to 6 mm, to 44.4% among patients with a lining of greater than or equal to 17 mm. ROC showed that endometrial thickness is not a good predictor of PR, so a definite cut-off value could not be established (AUC = 0.55). CONCLUSION: There is a positive linear relationship between the endometrial thickness measured on the day of hCG injection and PR, and is independent of other variables. Hence aiming for a thicker endometrium should be considered. BioMed Central 2008-09-02 /pmc/articles/PMC2543019/ /pubmed/18764940 http://dx.doi.org/10.1186/1477-7827-6-37 Text en Copyright © 2008 Al-Ghamdi et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Al-Ghamdi, Ahlam
Coskun, Serdar
Al-Hassan, Saad
Al-Rejjal, Rafat
Awartani, Khalid
The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome
title The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome
title_full The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome
title_fullStr The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome
title_full_unstemmed The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome
title_short The correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (IVF-ET) outcome
title_sort correlation between endometrial thickness and outcome of in vitro fertilization and embryo transfer (ivf-et) outcome
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543019/
https://www.ncbi.nlm.nih.gov/pubmed/18764940
http://dx.doi.org/10.1186/1477-7827-6-37
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