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Transcriptional regulation of long-term memory in the marine snail Aplysia

Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new protein synthesis. On the cellular level, transcriptional regulation is thought to be the sta...

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Autores principales: Lee, Yong-Seok, Bailey, Craig H, Kandel, Eric R, Kaang, Bong-Kiun
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546398/
https://www.ncbi.nlm.nih.gov/pubmed/18803855
http://dx.doi.org/10.1186/1756-6606-1-3
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author Lee, Yong-Seok
Bailey, Craig H
Kandel, Eric R
Kaang, Bong-Kiun
author_facet Lee, Yong-Seok
Bailey, Craig H
Kandel, Eric R
Kaang, Bong-Kiun
author_sort Lee, Yong-Seok
collection PubMed
description Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new protein synthesis. On the cellular level, transcriptional regulation is thought to be the starting point for a series of molecular steps necessary for both the initiation and maintenance of long-term synaptic facilitation (LTF). The core molecular features of transcriptional regulation involved in the long-term process are evolutionally conserved in Aplysia, Drosophila, and mouse, and indicate that gene regulation by the cyclic AMP response element binding protein (CREB) acting in conjunction with different combinations of transcriptional factors is critical for the expression of many forms of long-term memory. In the marine snail Aplysia, the molecular mechanisms that underlie the storage of long-term memory have been extensively studied in the monosynaptic connections between identified sensory neuron and motor neurons of the gill-withdrawal reflex. One tail shock or one pulse of serotonin (5-HT), a modulatory transmitter released by tail shocks, produces a transient facilitation mediated by the cAMP-dependent protein kinase leading to covalent modifications in the sensory neurons that results in an enhancement of transmitter release and a strengthening of synaptic connections lasting minutes. By contrast, repeated pulses of 5-hydroxytryptamine (5-HT) induce a transcription- and translation-dependent long-term facilitation (LTF) lasting more than 24 h and trigger the activation of a family of transcription factors in the presynaptic sensory neurons including ApCREB1, ApCREB2 and ApC/EBP. In addition, we have recently identified novel transcription factors that modulate the expression of ApC/EBP and also are critically involved in LTF. In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms.
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spelling pubmed-25463982008-09-20 Transcriptional regulation of long-term memory in the marine snail Aplysia Lee, Yong-Seok Bailey, Craig H Kandel, Eric R Kaang, Bong-Kiun Mol Brain Review Whereas the induction of short-term memory involves only covalent modifications of constitutively expressed preexisting proteins, the formation of long-term memory requires gene expression, new RNA, and new protein synthesis. On the cellular level, transcriptional regulation is thought to be the starting point for a series of molecular steps necessary for both the initiation and maintenance of long-term synaptic facilitation (LTF). The core molecular features of transcriptional regulation involved in the long-term process are evolutionally conserved in Aplysia, Drosophila, and mouse, and indicate that gene regulation by the cyclic AMP response element binding protein (CREB) acting in conjunction with different combinations of transcriptional factors is critical for the expression of many forms of long-term memory. In the marine snail Aplysia, the molecular mechanisms that underlie the storage of long-term memory have been extensively studied in the monosynaptic connections between identified sensory neuron and motor neurons of the gill-withdrawal reflex. One tail shock or one pulse of serotonin (5-HT), a modulatory transmitter released by tail shocks, produces a transient facilitation mediated by the cAMP-dependent protein kinase leading to covalent modifications in the sensory neurons that results in an enhancement of transmitter release and a strengthening of synaptic connections lasting minutes. By contrast, repeated pulses of 5-hydroxytryptamine (5-HT) induce a transcription- and translation-dependent long-term facilitation (LTF) lasting more than 24 h and trigger the activation of a family of transcription factors in the presynaptic sensory neurons including ApCREB1, ApCREB2 and ApC/EBP. In addition, we have recently identified novel transcription factors that modulate the expression of ApC/EBP and also are critically involved in LTF. In this review, we examine the roles of these transcription factors during consolidation of LTF induced by different stimulation paradigms. BioMed Central 2008-06-17 /pmc/articles/PMC2546398/ /pubmed/18803855 http://dx.doi.org/10.1186/1756-6606-1-3 Text en Copyright © 2008 Lee et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lee, Yong-Seok
Bailey, Craig H
Kandel, Eric R
Kaang, Bong-Kiun
Transcriptional regulation of long-term memory in the marine snail Aplysia
title Transcriptional regulation of long-term memory in the marine snail Aplysia
title_full Transcriptional regulation of long-term memory in the marine snail Aplysia
title_fullStr Transcriptional regulation of long-term memory in the marine snail Aplysia
title_full_unstemmed Transcriptional regulation of long-term memory in the marine snail Aplysia
title_short Transcriptional regulation of long-term memory in the marine snail Aplysia
title_sort transcriptional regulation of long-term memory in the marine snail aplysia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546398/
https://www.ncbi.nlm.nih.gov/pubmed/18803855
http://dx.doi.org/10.1186/1756-6606-1-3
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