Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?

Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the...

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Detalles Bibliográficos
Autores principales: Frankland, Paul W, Sakaguchi, Masanori, Arruda-Carvalho, Maithé
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546401/
https://www.ncbi.nlm.nih.gov/pubmed/18803858
http://dx.doi.org/10.1186/1756-6606-1-5
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author Frankland, Paul W
Sakaguchi, Masanori
Arruda-Carvalho, Maithé
author_facet Frankland, Paul W
Sakaguchi, Masanori
Arruda-Carvalho, Maithé
author_sort Frankland, Paul W
collection PubMed
description Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, raising the possibility that disrupted adult neurogenesis lies at the core of this and other psychiatric disorders.
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spelling pubmed-25464012008-09-20 Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia? Frankland, Paul W Sakaguchi, Masanori Arruda-Carvalho, Maithé Mol Brain Editorial Using an endophenotype-driven screen, a new study finds that α-calcium/calmodulin kinase II mutant mice exhibit a range of behavioral abnormalities related to schizophrenia. Perhaps most strikingly, this cluster of schizophrenia-related endophenotypes was associated with abnormal neurogenesis in the adult hippocampus, raising the possibility that disrupted adult neurogenesis lies at the core of this and other psychiatric disorders. BioMed Central 2008-09-10 /pmc/articles/PMC2546401/ /pubmed/18803858 http://dx.doi.org/10.1186/1756-6606-1-5 Text en Copyright © 2008 Frankland et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editorial
Frankland, Paul W
Sakaguchi, Masanori
Arruda-Carvalho, Maithé
Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
title Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
title_full Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
title_fullStr Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
title_full_unstemmed Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
title_short Starting at the endophenotype: A role for alpha-CaMKII in schizophrenia?
title_sort starting at the endophenotype: a role for alpha-camkii in schizophrenia?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546401/
https://www.ncbi.nlm.nih.gov/pubmed/18803858
http://dx.doi.org/10.1186/1756-6606-1-5
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