Anti-inflammatory effects of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) in animal models

BACKGROUND: KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects. METHODS: Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of t...

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Detalles Bibliográficos
Autores principales: Kim, Kyoung Soo, Rhee, Hae In, Park, Eun Kyung, Jung, Kiwon, Jeon, Hyo Jin, Kim, Ji-Hong, Yoo, Hunseung, Han, Chang-Kyun, Cho, Yong-Baik, Ryu, Chun Jeih, Yang, Hyung In, Yoo, Myung Chul
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546402/
https://www.ncbi.nlm.nih.gov/pubmed/18761750
http://dx.doi.org/10.1186/1749-8546-3-10
Descripción
Sumario:BACKGROUND: KHU14, an ethanolic extract of Radix Gentianae Macrophyllae (Qinjiao), Rhizoma Coptidis (Huanglian) and Citri Unshiu Pericarpium (Wenzhou migan) was tested for its anti-inflammatory effects. METHODS: Three out of 20 herbs were found to have anti-inflammatory effects. The formulation of these herbs, i.e. KHU14 was tested for croton oil-induced ear edema, carrageenan-induced paw edema, acetic acid-induced capillary permeability, cotton pellet and delayed type hypersensitivity. RESULTS: KHU14 exhibited anti-inflammatory effects in animal models of acute and chronic inflammation. The anti-inflammatory activity of KHU14 observed was comparable to that of celecoxib. KHU14 inhibited the production of NO and PGE(2 )in LPS/IFN-gamma-stimulated peritoneal macrophages, and reduced edema and the amount of infiltrated cells in animal models. CONCLUSION: KHU14 exhibited anti-inflammatory effects as demonstrated in typical immunological tests for anti-inflammation in vitro and in vivo.

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