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Cytoplasmic signaling in the control of mitochondrial uproar?

The concept of a pre-emptive strike as a good means to prevent greater harm may be frequently over-stressed in daily life. However, biological systems in a homeostatic balance are prepared to withstand a certain degree of hostile fire by rather passive means. This also applies to the maintenance of...

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Detalles Bibliográficos
Autores principales: Hermann, Martin, Kuznetsov, Andrey, Maglione, Manuel, Smigelskaite, Julija, Margreiter, Raimund, Troppmair, Jakob
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546410/
https://www.ncbi.nlm.nih.gov/pubmed/18713454
http://dx.doi.org/10.1186/1478-811X-6-4
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author Hermann, Martin
Kuznetsov, Andrey
Maglione, Manuel
Smigelskaite, Julija
Margreiter, Raimund
Troppmair, Jakob
author_facet Hermann, Martin
Kuznetsov, Andrey
Maglione, Manuel
Smigelskaite, Julija
Margreiter, Raimund
Troppmair, Jakob
author_sort Hermann, Martin
collection PubMed
description The concept of a pre-emptive strike as a good means to prevent greater harm may be frequently over-stressed in daily life. However, biological systems in a homeostatic balance are prepared to withstand a certain degree of hostile fire by rather passive means. This also applies to the maintenance of cell survival, where a plethora of protective proteins provide safeguard against erroneous activation of death pathways. Apart from these mechanisms active processes are also essential for the maintenance of cellular homeostasis, commonly referred to as survival signaling. Frequently their targets may be mitochondrial, assuring organelle integrity, which is essential for continued energy production and survival. Transient or permanent failures in these cellular defense strategies result in pathophysiological conditions, which manifest themselves e.g. as cancer or ischemia/reperfusion-associated organ damage.
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spelling pubmed-25464102008-09-20 Cytoplasmic signaling in the control of mitochondrial uproar? Hermann, Martin Kuznetsov, Andrey Maglione, Manuel Smigelskaite, Julija Margreiter, Raimund Troppmair, Jakob Cell Commun Signal Review The concept of a pre-emptive strike as a good means to prevent greater harm may be frequently over-stressed in daily life. However, biological systems in a homeostatic balance are prepared to withstand a certain degree of hostile fire by rather passive means. This also applies to the maintenance of cell survival, where a plethora of protective proteins provide safeguard against erroneous activation of death pathways. Apart from these mechanisms active processes are also essential for the maintenance of cellular homeostasis, commonly referred to as survival signaling. Frequently their targets may be mitochondrial, assuring organelle integrity, which is essential for continued energy production and survival. Transient or permanent failures in these cellular defense strategies result in pathophysiological conditions, which manifest themselves e.g. as cancer or ischemia/reperfusion-associated organ damage. BioMed Central 2008-08-19 /pmc/articles/PMC2546410/ /pubmed/18713454 http://dx.doi.org/10.1186/1478-811X-6-4 Text en Copyright © 2008 Hermann et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Hermann, Martin
Kuznetsov, Andrey
Maglione, Manuel
Smigelskaite, Julija
Margreiter, Raimund
Troppmair, Jakob
Cytoplasmic signaling in the control of mitochondrial uproar?
title Cytoplasmic signaling in the control of mitochondrial uproar?
title_full Cytoplasmic signaling in the control of mitochondrial uproar?
title_fullStr Cytoplasmic signaling in the control of mitochondrial uproar?
title_full_unstemmed Cytoplasmic signaling in the control of mitochondrial uproar?
title_short Cytoplasmic signaling in the control of mitochondrial uproar?
title_sort cytoplasmic signaling in the control of mitochondrial uproar?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546410/
https://www.ncbi.nlm.nih.gov/pubmed/18713454
http://dx.doi.org/10.1186/1478-811X-6-4
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