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Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK

BACKGROUND: To elucidate the role of src kinase in caveolin-1 driven internalization and nuclear transport of EGFR linked to regulation of DNA-repair in irradiated cells. RESULTS: Ionizing radiation resulted in src kinase stabilization, activation and subsequent src mediated caveolin-1 Y14- and EGFR...

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Detalles Bibliográficos
Autores principales:	Dittmann, Klaus, Mayer, Claus, Kehlbach, Rainer, Rodemann, H Peter
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546440/ https://www.ncbi.nlm.nih.gov/pubmed/18789131 http://dx.doi.org/10.1186/1476-4598-7-69

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