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Cancer Genes Hypermethylated in Human Embryonic Stem Cells
Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546447/ https://www.ncbi.nlm.nih.gov/pubmed/18820729 http://dx.doi.org/10.1371/journal.pone.0003294 |
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| author | Calvanese, Vincenzo Horrillo, Angelica Hmadcha, Abdelkrim Suarez-Álvarez, Beatriz Fernandez, Agustín F. Lara, Ester Casado, Sara Menendez, Pablo Bueno, Clara Garcia-Castro, Javier Rubio, Ruth Lapunzina, Pablo Alaminos, Miguel Borghese, Lodovica Terstegge, Stefanie Harrison, Neil J. Moore, Harry D. Brüstle, Oliver Lopez-Larrea, Carlos Andrews, Peter W. Soria, Bernat Esteller, Manel Fraga, Mario F. |
| author_facet | Calvanese, Vincenzo Horrillo, Angelica Hmadcha, Abdelkrim Suarez-Álvarez, Beatriz Fernandez, Agustín F. Lara, Ester Casado, Sara Menendez, Pablo Bueno, Clara Garcia-Castro, Javier Rubio, Ruth Lapunzina, Pablo Alaminos, Miguel Borghese, Lodovica Terstegge, Stefanie Harrison, Neil J. Moore, Harry D. Brüstle, Oliver Lopez-Larrea, Carlos Andrews, Peter W. Soria, Bernat Esteller, Manel Fraga, Mario F. |
| author_sort | Calvanese, Vincenzo |
| collection | PubMed |
| description | Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in human stem cells and suggest that, for genes repressed by promoter hypermethylation in stem cells in vivo, the aberrant process in cancer could be understood as a defect in establishing an unmethylated promoter during differentiation, rather than as an anomalous process of de novo hypermethylation. |
| format | Text |
| id | pubmed-2546447 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-25464472008-09-29 Cancer Genes Hypermethylated in Human Embryonic Stem Cells Calvanese, Vincenzo Horrillo, Angelica Hmadcha, Abdelkrim Suarez-Álvarez, Beatriz Fernandez, Agustín F. Lara, Ester Casado, Sara Menendez, Pablo Bueno, Clara Garcia-Castro, Javier Rubio, Ruth Lapunzina, Pablo Alaminos, Miguel Borghese, Lodovica Terstegge, Stefanie Harrison, Neil J. Moore, Harry D. Brüstle, Oliver Lopez-Larrea, Carlos Andrews, Peter W. Soria, Bernat Esteller, Manel Fraga, Mario F. PLoS One Research Article Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant proportion of these TSGs in human embryonic and adult stem cells is associated with promoter DNA hypermethylation. Our results indicate a role for DNA methylation in the control of gene expression in human stem cells and suggest that, for genes repressed by promoter hypermethylation in stem cells in vivo, the aberrant process in cancer could be understood as a defect in establishing an unmethylated promoter during differentiation, rather than as an anomalous process of de novo hypermethylation. Public Library of Science 2008-09-29 /pmc/articles/PMC2546447/ /pubmed/18820729 http://dx.doi.org/10.1371/journal.pone.0003294 Text en Calvanese et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Calvanese, Vincenzo Horrillo, Angelica Hmadcha, Abdelkrim Suarez-Álvarez, Beatriz Fernandez, Agustín F. Lara, Ester Casado, Sara Menendez, Pablo Bueno, Clara Garcia-Castro, Javier Rubio, Ruth Lapunzina, Pablo Alaminos, Miguel Borghese, Lodovica Terstegge, Stefanie Harrison, Neil J. Moore, Harry D. Brüstle, Oliver Lopez-Larrea, Carlos Andrews, Peter W. Soria, Bernat Esteller, Manel Fraga, Mario F. Cancer Genes Hypermethylated in Human Embryonic Stem Cells |
| title | Cancer Genes Hypermethylated in Human Embryonic Stem Cells |
| title_full | Cancer Genes Hypermethylated in Human Embryonic Stem Cells |
| title_fullStr | Cancer Genes Hypermethylated in Human Embryonic Stem Cells |
| title_full_unstemmed | Cancer Genes Hypermethylated in Human Embryonic Stem Cells |
| title_short | Cancer Genes Hypermethylated in Human Embryonic Stem Cells |
| title_sort | cancer genes hypermethylated in human embryonic stem cells |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546447/ https://www.ncbi.nlm.nih.gov/pubmed/18820729 http://dx.doi.org/10.1371/journal.pone.0003294 |
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