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Cancer Genes Hypermethylated in Human Embryonic Stem Cells

Developmental genes are silenced in embryonic stem cells by a bivalent histone-based chromatin mark. It has been proposed that this mark also confers a predisposition to aberrant DNA promoter hypermethylation of tumor suppressor genes (TSGs) in cancer. We report here that silencing of a significant...

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Detalles Bibliográficos
Autores principales:	Calvanese, Vincenzo, Horrillo, Angelica, Hmadcha, Abdelkrim, Suarez-Álvarez, Beatriz, Fernandez, Agustín F., Lara, Ester, Casado, Sara, Menendez, Pablo, Bueno, Clara, Garcia-Castro, Javier, Rubio, Ruth, Lapunzina, Pablo, Alaminos, Miguel, Borghese, Lodovica, Terstegge, Stefanie, Harrison, Neil J., Moore, Harry D., Brüstle, Oliver, Lopez-Larrea, Carlos, Andrews, Peter W., Soria, Bernat, Esteller, Manel, Fraga, Mario F.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546447/ https://www.ncbi.nlm.nih.gov/pubmed/18820729 http://dx.doi.org/10.1371/journal.pone.0003294

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