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Atorvastatin and cardiovascular risk in the elderly – patient considerations

Elderly individuals are at increased risk of coronary heart disease (CHD) and account for a majority of CHD deaths. Several clinical trials have assessed the beneficial effects of statins in individuals with, or at risk of developing, CHD. These trials provide evidence that statins reduce risk and i...

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Detalles Bibliográficos
Autores principales: Acharjee, Subroto, Welty, Francine K
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546474/
https://www.ncbi.nlm.nih.gov/pubmed/18686752
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author Acharjee, Subroto
Welty, Francine K
author_facet Acharjee, Subroto
Welty, Francine K
author_sort Acharjee, Subroto
collection PubMed
description Elderly individuals are at increased risk of coronary heart disease (CHD) and account for a majority of CHD deaths. Several clinical trials have assessed the beneficial effects of statins in individuals with, or at risk of developing, CHD. These trials provide evidence that statins reduce risk and improve clinical outcomes even in older patients; however, statin therapy remains under-utilized among the aged. Atorvastatin has been widely investigated among the older subjects and has the greatest magnitude of favorable effects on clinical outcomes of CHD. The pharmacokinetic properties of atorvastatin allow it to be used every other day, a factor which may decrease adverse events and be especially important in the elderly. The purpose of this article is to review the evidence available from randomized clinical trials regarding the safety and efficacy of atorvastatin in primary and secondary prevention of CHD and stroke in older patients and to discuss issues such as drug interactions, patient compliance and cost-effectiveness, which affect prescription of lipid-lowering therapy among older patients.
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spelling pubmed-25464742009-05-20 Atorvastatin and cardiovascular risk in the elderly – patient considerations Acharjee, Subroto Welty, Francine K Clin Interv Aging Review Elderly individuals are at increased risk of coronary heart disease (CHD) and account for a majority of CHD deaths. Several clinical trials have assessed the beneficial effects of statins in individuals with, or at risk of developing, CHD. These trials provide evidence that statins reduce risk and improve clinical outcomes even in older patients; however, statin therapy remains under-utilized among the aged. Atorvastatin has been widely investigated among the older subjects and has the greatest magnitude of favorable effects on clinical outcomes of CHD. The pharmacokinetic properties of atorvastatin allow it to be used every other day, a factor which may decrease adverse events and be especially important in the elderly. The purpose of this article is to review the evidence available from randomized clinical trials regarding the safety and efficacy of atorvastatin in primary and secondary prevention of CHD and stroke in older patients and to discuss issues such as drug interactions, patient compliance and cost-effectiveness, which affect prescription of lipid-lowering therapy among older patients. Dove Medical Press 2008-06 2008-06 /pmc/articles/PMC2546474/ /pubmed/18686752 Text en © 2008 Dove Medical Press Limited. All rights reserved
spellingShingle Review
Acharjee, Subroto
Welty, Francine K
Atorvastatin and cardiovascular risk in the elderly – patient considerations
title Atorvastatin and cardiovascular risk in the elderly – patient considerations
title_full Atorvastatin and cardiovascular risk in the elderly – patient considerations
title_fullStr Atorvastatin and cardiovascular risk in the elderly – patient considerations
title_full_unstemmed Atorvastatin and cardiovascular risk in the elderly – patient considerations
title_short Atorvastatin and cardiovascular risk in the elderly – patient considerations
title_sort atorvastatin and cardiovascular risk in the elderly – patient considerations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2546474/
https://www.ncbi.nlm.nih.gov/pubmed/18686752
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