Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses

This paper describes an instrumentation system for positron emission tomography (PET). A variety of [1-(11)C]labelled aldoses, such as [1-(11)C]-D-glucose, and galactose by a modification of the Kiliani-Fischer method have been produced. The instrumentation is fully automatic and consists of a synth...

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Detalles Bibliográficos
Autores principales: Nishimura, Shintaro, Yajima, Kazuyoshi, Harada, Norihiro, Ogawa, Yasuhiro, Hayashi, Nobuyoshi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2548034/
https://www.ncbi.nlm.nih.gov/pubmed/18924991
http://dx.doi.org/10.1155/S1463924694000246
Descripción
Sumario:This paper describes an instrumentation system for positron emission tomography (PET). A variety of [1-(11)C]labelled aldoses, such as [1-(11)C]-D-glucose, and galactose by a modification of the Kiliani-Fischer method have been produced. The instrumentation is fully automatic and consists of a synthesis system and control system. The synthesis system has the following functions: supplying reagents; performing reactions; purifying (11)C labelled aldose; and preparing an injectable solution of (11)C labelled aldose. These operations are performed by the control system in a remote control room. In a preliminary, hot experiment an injectable solution of [1-(11)C]-D-glucose was obtained. In addition, the operator is exposed to minimal radiation. The radioactivity of [1-(11)C]-Dglucose was 47 MBq, and the preparation time was 49 min.

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