Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses

This paper describes an instrumentation system for positron emission tomography (PET). A variety of [1-(11)C]labelled aldoses, such as [1-(11)C]-D-glucose, and galactose by a modification of the Kiliani-Fischer method have been produced. The instrumentation is fully automatic and consists of a synth...

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Detalles Bibliográficos
Autores principales: Nishimura, Shintaro, Yajima, Kazuyoshi, Harada, Norihiro, Ogawa, Yasuhiro, Hayashi, Nobuyoshi
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 1994
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2548034/
https://www.ncbi.nlm.nih.gov/pubmed/18924991
http://dx.doi.org/10.1155/S1463924694000246
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author Nishimura, Shintaro
Yajima, Kazuyoshi
Harada, Norihiro
Ogawa, Yasuhiro
Hayashi, Nobuyoshi
author_facet Nishimura, Shintaro
Yajima, Kazuyoshi
Harada, Norihiro
Ogawa, Yasuhiro
Hayashi, Nobuyoshi
author_sort Nishimura, Shintaro
collection PubMed
description This paper describes an instrumentation system for positron emission tomography (PET). A variety of [1-(11)C]labelled aldoses, such as [1-(11)C]-D-glucose, and galactose by a modification of the Kiliani-Fischer method have been produced. The instrumentation is fully automatic and consists of a synthesis system and control system. The synthesis system has the following functions: supplying reagents; performing reactions; purifying (11)C labelled aldose; and preparing an injectable solution of (11)C labelled aldose. These operations are performed by the control system in a remote control room. In a preliminary, hot experiment an injectable solution of [1-(11)C]-D-glucose was obtained. In addition, the operator is exposed to minimal radiation. The radioactivity of [1-(11)C]-Dglucose was 47 MBq, and the preparation time was 49 min.
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spelling pubmed-25480342008-10-16 Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses Nishimura, Shintaro Yajima, Kazuyoshi Harada, Norihiro Ogawa, Yasuhiro Hayashi, Nobuyoshi J Automat Chem Research Article This paper describes an instrumentation system for positron emission tomography (PET). A variety of [1-(11)C]labelled aldoses, such as [1-(11)C]-D-glucose, and galactose by a modification of the Kiliani-Fischer method have been produced. The instrumentation is fully automatic and consists of a synthesis system and control system. The synthesis system has the following functions: supplying reagents; performing reactions; purifying (11)C labelled aldose; and preparing an injectable solution of (11)C labelled aldose. These operations are performed by the control system in a remote control room. In a preliminary, hot experiment an injectable solution of [1-(11)C]-D-glucose was obtained. In addition, the operator is exposed to minimal radiation. The radioactivity of [1-(11)C]-Dglucose was 47 MBq, and the preparation time was 49 min. Hindawi Publishing Corporation 1994 /pmc/articles/PMC2548034/ /pubmed/18924991 http://dx.doi.org/10.1155/S1463924694000246 Text en Copyright © 1994 Hindawi Publishing Corporation. http://creativecommons.org/licenses/by/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nishimura, Shintaro
Yajima, Kazuyoshi
Harada, Norihiro
Ogawa, Yasuhiro
Hayashi, Nobuyoshi
Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses
title Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses
title_full Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses
title_fullStr Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses
title_full_unstemmed Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses
title_short Automated synthesis of radiopharmaceuticals for PET: an apparatus for [1-(11)C]labelled aldoses
title_sort automated synthesis of radiopharmaceuticals for pet: an apparatus for [1-(11)c]labelled aldoses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2548034/
https://www.ncbi.nlm.nih.gov/pubmed/18924991
http://dx.doi.org/10.1155/S1463924694000246
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