Cargando…

Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial

OBJECTIVE—The purpose of this study was to evaluate whether severe hypoglycemia or intensive therapy affects cognitive performance over time in a subgroup of patients who were aged 13–19 years at entry in the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS—This was a lon...

Descripción completa

Detalles Bibliográficos
Autores principales: Musen, Gail, Jacobson, Alan M., Ryan, Christopher M., Cleary, Patricia A., Waberski, Barbara H., Weinger, Katie, Dahms, William, Bayless, Meg, Silvers, Nancy, Harth, Judith, White, Neil
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551630/
https://www.ncbi.nlm.nih.gov/pubmed/18606979
http://dx.doi.org/10.2337/dc08-0607
_version_ 1782159449634373632
author Musen, Gail
Jacobson, Alan M.
Ryan, Christopher M.
Cleary, Patricia A.
Waberski, Barbara H.
Weinger, Katie
Dahms, William
Bayless, Meg
Silvers, Nancy
Harth, Judith
White, Neil
author_facet Musen, Gail
Jacobson, Alan M.
Ryan, Christopher M.
Cleary, Patricia A.
Waberski, Barbara H.
Weinger, Katie
Dahms, William
Bayless, Meg
Silvers, Nancy
Harth, Judith
White, Neil
author_sort Musen, Gail
collection PubMed
description OBJECTIVE—The purpose of this study was to evaluate whether severe hypoglycemia or intensive therapy affects cognitive performance over time in a subgroup of patients who were aged 13–19 years at entry in the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS—This was a longitudinal study involving 249 patients with type 1 diabetes who were between 13 and 19 years old when they were randomly assigned in the DCCT. Scores on a comprehensive battery of cognitive tests obtained during the Epidemiology of Diabetes Interventions and Complications follow-up study, ∼18 years later, were compared with baseline performance. We assessed the effects of the original DCCT treatment group assignment, mean A1C values, and frequency of severe hypoglycemic events on eight domains of cognition. RESULTS—There were a total of 294 reported episodes of coma or seizure. Neither frequency of hypoglycemia nor previous treatment group was associated with decline on any cognitive domain. As in a previous analysis of the entire study cohort, higher A1C values were associated with declines in the psychomotor and mental efficiency domain (P < 0.01); however, the previous finding of improved motor speed with lower A1C values was not replicated in this subgroup analysis. CONCLUSIONS—Despite relatively high rates of severe hypoglycemia, cognitive function did not decline over an extended period of time in the youngest cohort of patients with type 1 diabetes.
format Text
id pubmed-2551630
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-25516302009-10-01 Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial Musen, Gail Jacobson, Alan M. Ryan, Christopher M. Cleary, Patricia A. Waberski, Barbara H. Weinger, Katie Dahms, William Bayless, Meg Silvers, Nancy Harth, Judith White, Neil Diabetes Care Clinical Care/Education/Nutrition/Psychosocial Research OBJECTIVE—The purpose of this study was to evaluate whether severe hypoglycemia or intensive therapy affects cognitive performance over time in a subgroup of patients who were aged 13–19 years at entry in the Diabetes Control and Complications Trial (DCCT). RESEARCH DESIGN AND METHODS—This was a longitudinal study involving 249 patients with type 1 diabetes who were between 13 and 19 years old when they were randomly assigned in the DCCT. Scores on a comprehensive battery of cognitive tests obtained during the Epidemiology of Diabetes Interventions and Complications follow-up study, ∼18 years later, were compared with baseline performance. We assessed the effects of the original DCCT treatment group assignment, mean A1C values, and frequency of severe hypoglycemic events on eight domains of cognition. RESULTS—There were a total of 294 reported episodes of coma or seizure. Neither frequency of hypoglycemia nor previous treatment group was associated with decline on any cognitive domain. As in a previous analysis of the entire study cohort, higher A1C values were associated with declines in the psychomotor and mental efficiency domain (P < 0.01); however, the previous finding of improved motor speed with lower A1C values was not replicated in this subgroup analysis. CONCLUSIONS—Despite relatively high rates of severe hypoglycemia, cognitive function did not decline over an extended period of time in the youngest cohort of patients with type 1 diabetes. American Diabetes Association 2008-10 /pmc/articles/PMC2551630/ /pubmed/18606979 http://dx.doi.org/10.2337/dc08-0607 Text en Copyright © 2008, American Diabetes Association https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Clinical Care/Education/Nutrition/Psychosocial Research
Musen, Gail
Jacobson, Alan M.
Ryan, Christopher M.
Cleary, Patricia A.
Waberski, Barbara H.
Weinger, Katie
Dahms, William
Bayless, Meg
Silvers, Nancy
Harth, Judith
White, Neil
Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial
title Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial
title_full Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial
title_fullStr Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial
title_full_unstemmed Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial
title_short Impact of Diabetes and Its Treatment on Cognitive Function Among Adolescents Who Participated in the Diabetes Control and Complications Trial
title_sort impact of diabetes and its treatment on cognitive function among adolescents who participated in the diabetes control and complications trial
topic Clinical Care/Education/Nutrition/Psychosocial Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551630/
https://www.ncbi.nlm.nih.gov/pubmed/18606979
http://dx.doi.org/10.2337/dc08-0607
work_keys_str_mv AT musengail impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT jacobsonalanm impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT ryanchristopherm impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT clearypatriciaa impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT waberskibarbarah impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT weingerkatie impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT dahmswilliam impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT baylessmeg impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT silversnancy impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT harthjudith impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT whiteneil impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial
AT impactofdiabetesanditstreatmentoncognitivefunctionamongadolescentswhoparticipatedinthediabetescontrolandcomplicationstrial