Mechanism of Oxidative DNA Damage in Diabetes : Tuberin Inactivation and Downregulation of DNA Repair Enzyme 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine-DNA Glycosylase

OBJECTIVE—To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells. RESEARCH DESIGN AND METHODS—Phosphorylation of Akt and tuberin, 8-oxo-7,8-dihydro-2′-d...

Descripción completa

Detalles Bibliográficos
Autores principales: Simone, Simona, Gorin, Yves, Velagapudi, Chakradhar, Abboud, Hanna E., Habib, Samy L.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2008
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551671/
https://www.ncbi.nlm.nih.gov/pubmed/18599524
http://dx.doi.org/10.2337/db07-1579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551671/
https://www.ncbi.nlm.nih.gov/pubmed/18599524
http://dx.doi.org/10.2337/db07-1579

Ejemplares similares