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Impaired Glucose Tolerance and Insulin Resistance Are Associated With Increased Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 Expression and Elevated Hepatic 5α-Reductase Activity

OBJECTIVE—The precise molecular mechanisms contributing to the development of insulin resistance, impaired glucose tolerance (IGT), and type 2 diabetes are largely unknown. Altered endogenous glucocorticoid metabolism, including 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which generates act...

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Detalles Bibliográficos
Autores principales:	Tomlinson, Jeremy W., Finney, Joanne, Gay, Christopher, Hughes, Beverly A., Hughes, Susan V., Stewart, Paul M.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Obesity Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551674/ https://www.ncbi.nlm.nih.gov/pubmed/18633104 http://dx.doi.org/10.2337/db08-0495

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