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Spontaneous Diabetes in Hemizygous Human Amylin Transgenic Mice That Developed Neither Islet Amyloid nor Peripheral Insulin Resistance

OBJECTIVES—We sought to 1) Determine whether soluble-misfolded amylin or insoluble-fibrillar amylin may cause or result from diabetes in human amylin transgenic mice and 2) determine the role, if any, that insulin resistance might play in these processes. RESEARCH DESIGN AND METHODS—We characterized...

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Detalles Bibliográficos
Autores principales:	Wong, Winifred P.S., Scott, David W., Chuang, Chia-Lin, Zhang, Shaoping, Liu, Hong, Ferreira, Athena, Saafi, Etuate L., Choong, Yee Soon, Cooper, Garth J.S.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2008
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2551684/ https://www.ncbi.nlm.nih.gov/pubmed/18633116 http://dx.doi.org/10.2337/db06-1755

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