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Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

BACKGROUND: Dengue virus (DV) infection is one of the most important mosquito-borne diseases in the tropics. Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam. Protective and/or pathog...

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Autores principales: Lan, Nguyen Thi Phuong, Kikuchi, Mihoko, Huong, Vu Thi Que, Ha, Do Quang, Thuy, Tran Thi, Tham, Vo Dinh, Tuan, Ha Manh, Tuong, Vo Van, Nga, Cao Thi Phi, Van Dat, Tran, Oyama, Toshifumi, Morita, Kouichi, Yasunami, Michio, Hirayama, Kenji
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553281/
https://www.ncbi.nlm.nih.gov/pubmed/18827882
http://dx.doi.org/10.1371/journal.pntd.0000304
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author Lan, Nguyen Thi Phuong
Kikuchi, Mihoko
Huong, Vu Thi Que
Ha, Do Quang
Thuy, Tran Thi
Tham, Vo Dinh
Tuan, Ha Manh
Tuong, Vo Van
Nga, Cao Thi Phi
Van Dat, Tran
Oyama, Toshifumi
Morita, Kouichi
Yasunami, Michio
Hirayama, Kenji
author_facet Lan, Nguyen Thi Phuong
Kikuchi, Mihoko
Huong, Vu Thi Que
Ha, Do Quang
Thuy, Tran Thi
Tham, Vo Dinh
Tuan, Ha Manh
Tuong, Vo Van
Nga, Cao Thi Phi
Van Dat, Tran
Oyama, Toshifumi
Morita, Kouichi
Yasunami, Michio
Hirayama, Kenji
author_sort Lan, Nguyen Thi Phuong
collection PubMed
description BACKGROUND: Dengue virus (DV) infection is one of the most important mosquito-borne diseases in the tropics. Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam. Protective and/or pathogenic T cell immunity is supposed to be important in the pathogenesis of DHF and DSS. METHODOLOGY/PRINCIPAL FINDINGS: To identify HLA alleles controlling T cell immunity against dengue virus (DV), we performed a hospital-based case control study at Children's Hospital No.2, Ho Chi Minh City (HCMC), and Vinh Long Province Hospital (VL) in Southern Vietnam from 2002 to 2005. A total of 211 and 418 patients with DHF and DSS, respectively, diagnosed according to the World Health Organization (WHO) criteria, were analyzed for their characteristic HLA-A, -B and -DRB1 alleles. Four hundred fifty healthy children (250 from HCMC and 200 from VL) of the same Kinh ethnicity were also analyzed as population background. In HLA class I, frequency of the HLA-A*24 showed increased tendency in both DHF and DSS patients, which reproduced a previous study. The frequency of A*24 with histidine at codon 70 (A*2402/03/10), based on main anchor binding site specificity analysis in DSS and DHF patients, was significantly higher than that in the population background groups (HCMC 02-03 DSS: OR = 1.89, P = 0.008, DHF: OR = 1.75, P = 0.033; VL 02-03 DSS: OR = 1.70, P = 0.03, DHF: OR = 1.46, P = 0.38; VL 04-05 DSS: OR = 2.09, P = 0.0075, DHF: OR = 2.02, P = 0.038). In HLA class II, the HLA-DRB1*0901 frequency was significantly decreased in secondary infection of DSS in VL 04-05 (OR = 0.35, P = 0.0025, Pc = 0.03). Moreover, the frequency of HLA-DRB1*0901 in particular was significantly decreased in DSS when compared with DHF in DEN-2 infection (P = 0.02). CONCLUSION: This study improves our understanding of the risk of HLA-class I for severe outcome of DV infection in the light of peptide anchor binding site and provides novel evidence that HLA-class II may control disease severity (DHF to DSS) in DV infection.
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spelling pubmed-25532812008-10-01 Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome Lan, Nguyen Thi Phuong Kikuchi, Mihoko Huong, Vu Thi Que Ha, Do Quang Thuy, Tran Thi Tham, Vo Dinh Tuan, Ha Manh Tuong, Vo Van Nga, Cao Thi Phi Van Dat, Tran Oyama, Toshifumi Morita, Kouichi Yasunami, Michio Hirayama, Kenji PLoS Negl Trop Dis Research Article BACKGROUND: Dengue virus (DV) infection is one of the most important mosquito-borne diseases in the tropics. Recently, the severe forms, dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), have become the leading cause of death among children in Southern Vietnam. Protective and/or pathogenic T cell immunity is supposed to be important in the pathogenesis of DHF and DSS. METHODOLOGY/PRINCIPAL FINDINGS: To identify HLA alleles controlling T cell immunity against dengue virus (DV), we performed a hospital-based case control study at Children's Hospital No.2, Ho Chi Minh City (HCMC), and Vinh Long Province Hospital (VL) in Southern Vietnam from 2002 to 2005. A total of 211 and 418 patients with DHF and DSS, respectively, diagnosed according to the World Health Organization (WHO) criteria, were analyzed for their characteristic HLA-A, -B and -DRB1 alleles. Four hundred fifty healthy children (250 from HCMC and 200 from VL) of the same Kinh ethnicity were also analyzed as population background. In HLA class I, frequency of the HLA-A*24 showed increased tendency in both DHF and DSS patients, which reproduced a previous study. The frequency of A*24 with histidine at codon 70 (A*2402/03/10), based on main anchor binding site specificity analysis in DSS and DHF patients, was significantly higher than that in the population background groups (HCMC 02-03 DSS: OR = 1.89, P = 0.008, DHF: OR = 1.75, P = 0.033; VL 02-03 DSS: OR = 1.70, P = 0.03, DHF: OR = 1.46, P = 0.38; VL 04-05 DSS: OR = 2.09, P = 0.0075, DHF: OR = 2.02, P = 0.038). In HLA class II, the HLA-DRB1*0901 frequency was significantly decreased in secondary infection of DSS in VL 04-05 (OR = 0.35, P = 0.0025, Pc = 0.03). Moreover, the frequency of HLA-DRB1*0901 in particular was significantly decreased in DSS when compared with DHF in DEN-2 infection (P = 0.02). CONCLUSION: This study improves our understanding of the risk of HLA-class I for severe outcome of DV infection in the light of peptide anchor binding site and provides novel evidence that HLA-class II may control disease severity (DHF to DSS) in DV infection. Public Library of Science 2008-10-01 /pmc/articles/PMC2553281/ /pubmed/18827882 http://dx.doi.org/10.1371/journal.pntd.0000304 Text en Lan et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lan, Nguyen Thi Phuong
Kikuchi, Mihoko
Huong, Vu Thi Que
Ha, Do Quang
Thuy, Tran Thi
Tham, Vo Dinh
Tuan, Ha Manh
Tuong, Vo Van
Nga, Cao Thi Phi
Van Dat, Tran
Oyama, Toshifumi
Morita, Kouichi
Yasunami, Michio
Hirayama, Kenji
Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome
title Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome
title_full Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome
title_fullStr Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome
title_full_unstemmed Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome
title_short Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome
title_sort protective and enhancing hla alleles, hla-drb1*0901 and hla-a*24, for severe forms of dengue virus infection, dengue hemorrhagic fever and dengue shock syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553281/
https://www.ncbi.nlm.nih.gov/pubmed/18827882
http://dx.doi.org/10.1371/journal.pntd.0000304
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