BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?

BACKGROUND: BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP), MLH1 methylation and microsatellite instability (MSI). We aim...

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Detalles Bibliográficos
Autores principales: Velho, Sérgia, Moutinho, Cátia, Cirnes, Luís, Albuquerque, Cristina, Hamelin, Richard, Schmitt, Fernando, Carneiro, Fátima, Oliveira, Carla, Seruca, Raquel
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553419/
https://www.ncbi.nlm.nih.gov/pubmed/18782444
http://dx.doi.org/10.1186/1471-2407-8-255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553419/
https://www.ncbi.nlm.nih.gov/pubmed/18782444
http://dx.doi.org/10.1186/1471-2407-8-255

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