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BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: Primary or secondary genetic events in colorectal carcinogenesis?
BACKGROUND: BRAF, KRAS and PIK3CA mutations are frequently found in sporadic colorectal cancer (CRC). In contrast to KRAS and PIK3CA mutations, BRAF mutations are associated with tumours harbouring CpG Island methylation phenotype (CIMP), MLH1 methylation and microsatellite instability (MSI). We aim...
Autores principales: | Velho, Sérgia, Moutinho, Cátia, Cirnes, Luís, Albuquerque, Cristina, Hamelin, Richard, Schmitt, Fernando, Carneiro, Fátima, Oliveira, Carla, Seruca, Raquel |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553419/ https://www.ncbi.nlm.nih.gov/pubmed/18782444 http://dx.doi.org/10.1186/1471-2407-8-255 |
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