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Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations

The role of Thr729 in modulating the enzymatic function of human topoisomerase I has been characterized by molecular dynamics (MD) simulation. In detail, the structural–dynamical behaviour of the Thr729Lys and the Thr729Pro mutants have been characterized because of their in vivo and in vitro functi...

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Detalles Bibliográficos
Autores principales:	Chillemi, Giovanni, D’Annessa, Ilda, Fiorani, Paola, Losasso, Carmen, Benedetti, Piero, Desideri, Alessandro
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2008
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553568/ https://www.ncbi.nlm.nih.gov/pubmed/18765473 http://dx.doi.org/10.1093/nar/gkn558

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