Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase

Nonhomologous end-joining (NHEJ) is an important pathway for the repair of DNA double-strand breaks (DSBs) and plays a critical role in maintaining genomic stability in mammalian cells. While Ku70/80 (Ku) functions in NHEJ as part of the DNA-dependent protein kinase (DNA-PK), genetic evidence indica...

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Detalles Bibliográficos
Autores principales: Cheung, Joyce C.Y., Salerno, Brenda, Hanakahi, Les A.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2008
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553570/
https://www.ncbi.nlm.nih.gov/pubmed/18776215
http://dx.doi.org/10.1093/nar/gkn572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553570/
https://www.ncbi.nlm.nih.gov/pubmed/18776215
http://dx.doi.org/10.1093/nar/gkn572

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