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Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells

BACKGROUND: Histone acetylation is an epigenetic modification involved in the regulation of gene expression, balanced by histone acetyl transferases and histone deacetylase (HDAC) enzymes. HDAC inhibitors (HDACi) induce growth arrest and cell death in transformed cells, and are currently in many cli...

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Detalles Bibliográficos
Autores principales:	Dejligbjerg, Marielle, Grauslund, Morten, Litman, Thomas, Collins, Laura, Qian, Xiaozhong, Jeffers, Michael, Lichenstein, Henri, Jensen, Peter Buhl, Sehested, Maxwell
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2008
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2553797/ https://www.ncbi.nlm.nih.gov/pubmed/18789133 http://dx.doi.org/10.1186/1476-4598-7-70

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